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Small bowel obstruction is a common reason for surgical admission. Most common reason for small bowel obstruction is adhesions, which account up to 70-80 % of small bowel obstructions. Large proportion of adhesive small bowel obstructions may be treated nonoperatively, but up to 50-60% may need surgical intervention. Current golden standard for surgical intervention is open adhesiolysis. Recently, retrospective studies have provided encouraging results of laparoscopic adhesiolysis for small bowel obstructions. However, no prospective randomized trials have been carried out and retrospective series carries a high risk for patient selection and bias. Although in general laparoscopy has been associated with shortened hospital stay, less pain and reduced mortality, laparoscopic adhesiolysis for small bowel obstruction has been reported to cause iatrogenic small bowel lesions up to 7% of patients. Aim of the study is to compare open adhesiolysis to laparoscopic adhesiolysis. The investigators hypothesis is that laparoscopic adhesiolysis is safe, will shorten the hospital stay, and reduce mortality compared to open approach.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laparoscopic adhesiolysis | Experimental |
| |
| Open adhesiolysis | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic adhesiolysis | Procedure |
| ||
| Open adhesiolysis |
| Measure | Description | Time Frame |
|---|---|---|
| Post-operative hospital stay (days) | Participants will be followed for the duration of post-operative hospital stay, an expected average of 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Passage of stools (post-operative days) | Participants will be followed for the duration of post-operative hospital stay, an expected average of 7 days | |
| Commence of enteral nutrition (post-operative days) | Participants will be followed for the duration of post-operative hospital stay, an expected average of 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ville Sallinen, MD, PhD | Helsinki University Central Hospital | Principal Investigator |
| Panu Mentula, MD, PhD | Helsinki University Central Hospital | Study Director |
| Ari Leppäniemi, MD, PhD | Helsinki University Central Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Helsinki University Central Hospital | Helsinki | Finland | ||||
| Päijät-Häme Central Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41706492 | Derived | Raty P, Mentula P, Haukijarvi E, Juusela R, Wikstrom H, Koivukangas V, Enholm B, Di Saverio S, Birindelli A, Catena F, Leppaniemi A, Sallinen V. Long-Term Outcomes After Laparoscopic vs Open Adhesiolysis for Small Bowel Obstruction: The LASSO Randomized Clinical Trial. JAMA Surg. 2026 Apr 1;161(4):381-388. doi: 10.1001/jamasurg.2025.6726. | |
| 25306234 |
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| Procedure |
|
| Mortality | 30 days after randomization |
| Complications, Clavien-Dindo classification | 30 days after randomization |
| Number of participants with iatrogenic small bowel lesions | Participants will be followed for the duration of post-operative hospital stay, an expected average of 7 days |
| Number of participants with readmission(s) | 30 days after randomization |
| Number of participant with failure to relieve obstruction | Participants will be followed for the duration of post-operative hospital stay, an expected average of 7 days |
| Pain scores on the Visual Analog Scale | Postoperative days 1- 7 or till discharge |
| Length of epidural catheter analgesia (days) | Participants will be followed for the duration of post-operative hospital stay, an expected average of 7 days |
| Total need of opioids in milligrams | Participants will be followed for the duration of post-operative hospital stay, an expected average of 7 days |
| Length of sick leave (days) | Participants will be followed for the duration of sick leave, depending on occupation estimated 1-4 weeks |
| Number of participants that develop ventral hernia | 10 years |
| Number of patient with recurrent adhesive small bowel obstruction | 10 years |
| Lahti |
| Finland |
| Oulu University Hospital | Oulu | Finland |
| Tampere University Hospital | Tampere | Finland |
| Vaasa Central Hospital | Vaasa | Finland |
| Peijas Hospital | Vantaa | Finland |
| Bologna Maggiore Hospital | Bologna | Italy |
| Parma University Hospital | Parma | Italy |
| Sallinen V, Wikstrom H, Victorzon M, Salminen P, Koivukangas V, Haukijarvi E, Enholm B, Leppaniemi A, Mentula P. Laparoscopic versus open adhesiolysis for small bowel obstruction - a multicenter, prospective, randomized, controlled trial. BMC Surg. 2014 Oct 11;14:77. doi: 10.1186/1471-2482-14-77. |