The purpose of this study is to determine the effect of aspirin desensitization on symptoms and immunologic profile of patients with aspirin-exacerbated respiratory diseases (AERD).

Inclusion Criteria:

• Patients with clinical diagnose of aspirin-exacerbated respiratory disease
• History of physician diagnosed asthma.
• History of physiacian diagnosed chronic rhinosinositis with nasal polyps.
• Positive reaction to aspirin challenge test.
• Stable asthma (post-bronchodilator FEV1 of 70% or better, no increase in baseline dose of oral glucocorticoids for at least 3 months, and no history of hospitalization or emergency room visits for asthma for at least the prior 6 months).

Exclusion Criteria:

• Being smoker
• pregnancy
• Current breastfeeding
• History of bleeding diathesis
• History of transient ischemic attack or stroke, or diabetes.
• History of abnormal hepatic function
• Uncontrolled hypertension or use of beta blocker medication.
• History of gastrointestinal ulcers or gastrointestinal bleeding.