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Chronic kidney disease (CKD) is associated with high level of peripheral arterial disease (PAD). This could lead wounds, infections then amputations or deaths by impairment of the peripheral cutaneous perfusion. Medical therapies are presently unable to cure, but only slow down these disorders. Impact of exercise and lower extremity PAD rehabilitation is decreased by the significant inactivity of the chronic hemodialysis patients. Recently, many studies have shown several various favorable effects of the perdialytic physical activity. There is currently no data about effects of the perdialytic activity on the lower extremity perfusion. The aim of this clinical study is to show the impact of three months perdialytic cycling on the microcirculation, in chronic hemodialysis patients. Primary outcome will be the increase of cutaneous perfusion, assessed by measuring transcutaneous oxygen pressure (tcPO2) on about twenty patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| single arm | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Three months of regular perdialytic physical activity (cycling) | Other | Cycling, in lying position, at a rate of thirty minutes per dialysis session (three a week), regardless of performance |
| Measure | Description | Time Frame |
|---|---|---|
| Increase of cutaneous lower extremity perfusion. | TcPO2 will be performed at the inclusion and just after the end of the three month study period |
| Measure | Description | Time Frame |
|---|---|---|
| Vascular assessment : Doppler and Index of systolic blood pressure | At the inclusion and after the end of the three month study period | |
| Related quality of life | at the inclusion and after the end of the three month study period |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Edouard Herriot | Lyon | 69003 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | Pelletier C., Jolivot A., Kalbacher E., Long A., Juillard L. Impact de la pratique d'une activité physique régulière perdialytique sur la microcirculation des membres inférieurs chez les patients hémodialysés chroniques : résultats de l'étude Activdial. Néphrologie & Thérapeutique. 2015;11(5):263. doi:10.1016/j.nephro.2015.07.015. | ||
| Result | Panaye, M., Jolivot, A., Lemoine, S., Villar, E., Fouque, D., & Laville, M. (2014). Outcome and prognosis factors of pregnancies in hemodialysis patients. Nephrology Dialysis Transplantation, 29(Suppl 3), iii520. Poster presented at the 51st ERA-EDTA Congress, Amsterdam, Netherlands. |
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| Appetite (score) | at the inclusion and after the end of the three month study period |
| Daily activity (Seven days pedometers) | at the inclusion and after the end of the three month study period |
| Protein intake (n-PCR) | at the inclusion and after the end of the three month study period |
| nutritional biological status (creatinin, albumin and transthyretin protein level) | at the inclusion and after the end of the three month study period |
| strength (handgrip test) | at the inclusion and after the end of the three month study period |