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| Name | Class |
|---|---|
| Lundbeck Foundation | OTHER |
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The purpose of this observational study is to evaluate the baroreceptor function in relation to surgical inflammation and orthostatic intolerance after elective hip arthroplasty.
The main hypothesis is that baroreceptor function is attenuated after surgery and related to surgical inflammation.
Orthostatic intolerance and hypotension is prevalent during early mobilization after major surgery.
This observational study aims to evaluate the baroreceptor function during using a standardized evaluation protocol before, 6- and 24 hours after elective primary unilateral hip-arthroplasty.
The study hypothesis is that baroreceptor function as expressed by the valsalva ratio is attenuated after surgery and related to surgical inflammation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study cohort |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in baroreceptor function from preoperatively to 6 hours after surgery | Change in baroreceptor function as expressed by change in the blood pressure valsalva ratio during a standardized assessment before and 6 hours after surgery. | 6 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Orthostatic response in blood pressure | The response in systolic and diastolic blood pressure during postural change from supine to standing | Preoperative, 6 and 24 hours after surgery |
| Orthostatic response in heart rate variability |
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Inclusion Criteria:
Exclusion Criteria:
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Patients scheduled for elective unilateral hip arthroplasty at Frederiksberg Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Øivind Jans, M.D | Contact | oeivind.jans@regionh.dk |
| Name | Affiliation | Role |
|---|---|---|
| Øivind Jans, M.D | Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Frederiksberg Hospital, Department of orthopaedic surgery | Recruiting | Frederiksberg | 2000 | Denmark |
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| ID | Term |
|---|---|
| D007024 | Hypotension, Orthostatic |
| ID | Term |
|---|---|
| D054971 | Orthostatic Intolerance |
| D054969 | Primary Dysautonomias |
| D001342 | Autonomic Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Blood samples for Hemoglobin measurement and plasma for inflammatory markers.
Heart rate variability during supine rest, sitting and standing as assessed by Spectral analysis.
| preoperative, 6 and 24 hours postoperative |
| Orthostatic intolerance | Orthostatic intolerance defined as the inability to sit or stand for 3 minutes due to presyncopal symptoms (Dizziness, Nausea, Blurred vision). | preoperative, 6 and 24 hours after surgery |
| Inflammatory markers | Inflammatory markers (CRP and interleukin-6) measured at 3 separate timepoint: preoperative, 6- and 24 h after surgery | preoperative, 6 and 24 hours postoperative |
| Orthostatic Hypotension | orthostatic hypotension defined according to international guidelines. | Preoperative, 6 and 24 hours postoperative. |
| Baroreceptor function | baroreceptor function as expressed by change in the blood pressure valsalva ratio during a standardized assessment | On the day of surgery: preoperatively, 6- and 24 hours after surgery |
| D007022 | Hypotension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |