The objective of the study is to assess the effect of motor, non-motor and genetic factors on the progression of Parkinson's disease as well as its impact on complications rates.

A large sample of Mexican subjects with Parkinson's disease attending several referral centers will be included.

Data collected will include disease severity and motor scales, non-motor scales as well as genotyping for monogenic forms of the disease.

Assessments will be performed every 6 months for two years.

Demographic and clinical data will be collected after obtaining a signed informed consent.

Recruitment will be competitive. Data collected includes age, gender, motor phenotype, age at onset, age at diagnosis, smoking history, family history, antiparkinsonic treatment, other treatments and a complete neurological evaluation.

Inclusion Criteria:

• Diagnosis of Parkinson's disease by the United Kingdom Parkinson's disease Society Brain Bank Criteria
• Any gender
• Any Hoehn and Yahr stage
• Written informed consent

Exclusion Criteria:

• Severe comorbidity that may limit proper neurological evaluation as judged by the investigator
• Subjects with atypical or secondary parkinsonism

Subjects diagnosed with idiopathic or genetic Parkinson's disease attending any of the participant sites in Mexico.