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Certain types of surgery are associated with occult blood loss, which is hard to detect intraoperatively by intermittent conventional, invasive Hb concentration measurements using the clinical standard of Hb monitoring by satellite laboratory analysis (Hbsatlab). The investigators want to see whether continuous non-invasive transcutaneous Hb measurement using a finger sensor (SpHb), (a) reduces the total time (area under the curve, AUC) a patient's Hb is below a predetermined transfusion threshold (HbAUC) for administration of red blood cell concentrate (RBC), and (b) prevents a decrease in total oxygen delivery (DO2) possibly associated with transfusion below a critical haemoglobin concentration. Furthermore, the investigators want to study if SpHb monitoring changes the timing of RBC administration and reduces the need for intra- and post-operative RBC transfusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hb group:15 patients | scheduled for elective surgery associated with undetected, i.e., difficult to reliably monitor intraoperative blood loss. |
| |
| SpHb group: 15 patients | scheduled for elective surgery associated with undetected, i.e., difficult to reliably monitor intraoperative blood loss. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood transfusion, intermittent Hbsatlab measurement | Procedure | In the Hbsatlab group, RBC administration and its timing will be based on intermittent Hbsatlab measurement (routine care) |
| Measure | Description | Time Frame |
|---|---|---|
| HbAUC | the total time a patient's Hb is below a predetermined transfusion threshold (HbAUC) for administration of red blood cell concentrate | during operation |
| Measure | Description | Time Frame |
|---|---|---|
| blood transfusions | the number of perioperative blood transfusions | intra- and post operative up to 48h |
| Measure | Description | Time Frame |
|---|---|---|
| DO2 | DO2 = oxygen delivery | intraoperative |
| serum concentrations of high-sensitive troponin T | serum concentrations of high-sensitive troponin T |
Inclusion Criteria:
Exclusion Criteria:
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30 adult patients scheduled for surgery associated with undetected, i.e., difficult to reliably monitor intraoperative blood loss
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| Name | Affiliation | Role |
|---|---|---|
| Michel M.R.F. Struys, Prof.dr | University of groningen,University Medical Center Groningen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Center Groningen | Groningen | Provincie Groningen | 9713EZ | Netherlands |
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| ID | Term |
|---|---|
| D001803 | Blood Transfusion |
| ID | Term |
|---|---|
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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| blood transfusion, based on continuous SpHb readings | Procedure | RBC administration and its timing will be based on continuous SpHb readings while Hbsatlab values, measured every 30 min. by an objective observer, will not be visible to the attending anaesthetist. |
|
| post operative up to 48h |
| serum concentrations of lactate | lactate | intra- and post operative up to 48h |
| StO2 | StO2 = peripheral tissue oxygenation by near-infrared spectroscopy | intraoperative |