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From clinical observation that some achalasia patients drink water to help swallow food, the investigators have proposed a systemic hot water drinking therapy. This study is to observe its efficacy on achalasia symptoms and explore its mechanism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hot water drinking therapy | Experimental | Hot water drinking before,after meal and before sleep |
|
| Pneumatic dilation | Active Comparator | Patients who are unsatisfied with hot water drinking therapy are to receive standard pneumatic dilation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hot water drinking therapy | Other | Drink 200ml hot water 3min before and after a meal. Swallow food with hot water and drink 200ml hot water before sleep |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline achalasia symptom score at 1 month | Dysphagia, Regurgitation and Chest Pain scores | baseline and 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with adverse effects | adverse effects of drinking water like distention, nausea and belching | Week 1 |
| Change from baseline in barium esophagram at 1 year | measure esophageal diameter |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yutang Ren, M.D. | Contact | +86-020-62786224 | renytpumc@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Meiyun Ke, M.D. | Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science | Recruiting | Beijing | 100730 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9649001 | Result | Triadafilopoulos G, Tsang HP, Segall GM. Hot water swallows improve symptoms and accelerate esophageal clearance in esophageal motility disorders. J Clin Gastroenterol. 1998 Jun;26(4):239-44. doi: 10.1097/00004836-199806000-00003. | |
| 23105999 | Result | Ren Y, Ke M, Fang X, Zhu L, Sun X, Wang Z, Wang R, Wei Z, Wen P, Xin H, Chang M. Response of esophagus to high and low temperatures in patients with achalasia. J Neurogastroenterol Motil. 2012 Oct;18(4):391-8. doi: 10.5056/jnm.2012.18.4.391. Epub 2012 Oct 9. |
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| ID | Term |
|---|---|
| D004931 | Esophageal Achalasia |
| ID | Term |
|---|---|
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
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| Pneumatic dilation | Procedure | Patients who are unsatisfied with hot water drinking therapy are to receive standard pneumatic dilation under endoscope |
|
| baseline and 1 year |
| Endoscopy at 1 year | esophageal bezoars and esophageal cancer | year 1 |
| Pneumatic dilation rate and relative efficacy | Patients who are unsatisfied with hot water drinking therapy are to receive pneumatic dilation | any time |
| Change from baseline in achalasia symptom score at 1 year | Dysphagia,Regurgitation and Chest Pain scores | baseline and 1 year |
| Change from baseline achalasia symptom scores at 5 years | Dysphagia,Regurgitation and Chest Pain scores | baseline and 5 years |
| Change from baseline in barium esophagram at 5 years | measure esophageal diameter | baseline and 5 years |
| Endoscopy at 5 years | esophageal bezoars and esophageal cancer | year 5 |
| D004066 | Digestive System Diseases |