The purpose of the study is to evaluate the effect of Melatonin (in a dosage of 14mg daily) for a better clinical outcome in the period three days post stroke.

Stroke is the third most common cause of stroke. The cascade of event is separated into hyperacute,,acute,sub-acute and chronic. In the acute, sub acute state there are mechanisms of inflammation apoptotic death and effect of free radicals. Melatonin was proved to effect these mechanisms and to have a favourable effect in different diseases. The aim of the study is to prove That the use of Melatonin in a higher dosage may have a anti-destructive effect in stoke.

Inclusion Criteria:

• within 72hours of ischemic stroke
• age 18-80
• both gender
• ability to sign consent form

Exclusion Criteria:

• intra-cerebral bleeding
• tumour of brain
• multiple sclerosis
• s/p craniotomy
• known allergy to melatonin