Seroprevalence of Hepatitis B and Immune Response to Hepatitis B Vaccination in Chinese College Students

At present, children less than 15 y of age have been regarded as a key group for hepatitis B immunization in China. However, there is not yet special immunization strategy for population above 15 y of age. In this study, we investigated the seroprevalence of hepatitis B and immune response to HB vaccine among Chinese college students to uncover the need on universal mass vaccination or booster immunization only for students with HBV vaccination history against hepatitis B in Chinese college students to inform decision making.

Inclusion Criteria:

• Male and female freshmen in one college in Liuzhou city of Guangxi Zhuang Autonomous Region

Exclusion Criteria for vaccination study:

• acute illness
• immunocompromised conditions
• renal insufficiency
• pregnancy
• allergic history to HB vaccine or yeast
• positive for any of HBsAg, anti-HBs or anti-HBc