Biomarkers Correlation With Volemia

Predictive Value of Biomarkers on Volemia, Extra and Intra Vascular Varation and Hydroelectrolytic Disorders in Different ICU Patients

The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7 of ICU admission are correlated with Intravascular volume assessed by Cr 51 on red blood cells (Day 2 and Day 7) and by I 125 on albumine Day 7. The correlation of these Biomarkers are also evaluted with other markers such as erythropoietin and catecholamines. 80 ICU patients are included.

Inclusion Criteria:

• 20 Cerebral Hemorrhage
• 20 Head Injury
• 20 post surgery non traumatic non neuro
• 20 Polytrauma patients

Exclusion Criteria:

• Heart failure NYHA III or IV
• Renal insufficiency creatinin clearance < 30 ml/mn
• age < 18 Y
• Pregnancy