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| ID | Type | Description | Link |
|---|---|---|---|
| 8KL2TR000112-05 | U.S. NIH Grant/Contract | View source |
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This study is designed to investigate whether the pupil response to slowly flashing colored lights is significantly altered in patients with glaucoma, as compared to a control group of subjects without glaucoma.
The pupils inside the eyes constrict in response to light stimulation. Different classes of cells within the human retina initiate this response. Recent research suggests that one of the ganglion cell types involved in this pupil response is affected by glaucoma. By measuring pupil responses to different colored lights, the function of this class of cells can be evaluated quickly, and without touching the eye. An advantage of pupil testing strategies is that they do not require subjective feedback from the subject about what they can see, as is required for standard visual field tests that are used in the clinic.
The main aim of this study is to measure and compare the pupil constriction that occurs in response to flickering red and blue lights in patients with glaucoma versus matched control patients without glaucoma. In addition, the subjects will be asked questions about their quality of life and it will be determined whether issues related to quality of life correlate to alterations in the pupil responses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subjects with glaucoma (Cases) | This group will consist of patients with glaucoma who are under care at the Ohio State University Havener Eye Institute. | ||
| Subjects without glaucoma (Controls) | This group will consist of matched controls who are free of glaucoma and other complications, and who received a comprehensive eye examination at the Ohio State University College of Optometry. |
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| Measure | Description | Time Frame |
|---|---|---|
| Pupil Response | Using fourier analysis, the pupil fluctuation evoked by blue and red flickering lights will be measured in glaucoma patients and compared to matched controls. | Single Visit: One Day |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of Life Survey | Subjects will fill out a questionnaire with questions that assess quality of life issues, and the results will be correlated to the pupil response data. | Single Visit: One Day |
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Inclusion Criteria:
Exclusion Criteria:
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Cases: Age 18 or older with diagnosed glaucoma of known severity Controls: Matched to Cases on age, sex, and race.
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| Name | Affiliation | Role |
|---|---|---|
| Andrew Hartwick, OD, PhD | OSU College of Optometry | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| OSU College of Optometry | Columbus | Ohio | 42310 | United States | ||
| Havener Eye Institute |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | Shorter P, Eren D, Jain SG, Hartwick ATE. 2014. The flashing light-induced pupil response (FLIPR) glaucoma study. Invest. Ophthalmol. & Vis. Sci. 55: E-abstract 5608. |
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| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| D005128 | Eye Diseases |
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
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| Columbus |
| Ohio |
| 43212 |
| United States |