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| Name | Class |
|---|---|
| German Foundation for Neurology | OTHER |
| Department of Molecular Neurology, Faculty of Medicine, University Erlangen-Nürnberg | OTHER |
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Persons with Morbus Parkinson commonly develop gait and balance disorders leading to dependence, loss of mobility and a high risk of falling.
This study investigates the effectiveness of a sensorimotor treadmill intervention to improve walking and balance abilities in persons with early stages of Parkinson's disease. The sensorimotor treadmill training is conducted on a special treadmill device which is challenging the participants by small oscillations. This intervention, which is supposed to simulate walking on natural, uneven surfaces, is compared to a conventional treadmill training.
Hypothesis: Sensorimotor treadmill training leads to larger improvements in walking and balance abilities as compared to conventional treadmill exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sensorimotor treadmill training | Experimental | specific treadmill control using oscillating platform |
|
| conventional treadmill training | Active Comparator | conventional treadmill control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| treadmill walking | Behavioral |
| ||
| Treadmill |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline Gait Speed | Self selected walking speed is assessed on a 10 meter walk distance | 8 weeks and 20 weeks |
| Change from Baseline Balance | Mini - Balance Evaluation Systems Test (Mini - BESTest), Postural Sway in the Romberg Test with eyes open and eyes closed for 30 seconds | 8 weeks and 20 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline Gait Performance | Two Minute Walk Test (2MWT), Timed "up-and-go" Test, Assessment of tempo-spatial gait parameters | 8 weeks and 20 weeks |
| Change from Baseline Mobility | Rivermead Mobility Index |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Klaus Pfeifer, Prof. Dr. | Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Sport Science and Sport | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Sport Science and Sport, Gebbertstr. 123b | Erlangen | 91058 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26655098 | Background | Klamroth S, Steib S, Devan S, Pfeifer K. Effects of Exercise Therapy on Postural Instability in Parkinson Disease: A Meta-analysis. J Neurol Phys Ther. 2016 Jan;40(1):3-14. doi: 10.1097/NPT.0000000000000117. | |
| 27591395 | Result | Klamroth S, Steib S, Gassner H, Gossler J, Winkler J, Eskofier B, Klucken J, Pfeifer K. Immediate effects of perturbation treadmill training on gait and postural control in patients with Parkinson's disease. Gait Posture. 2016 Oct;50:102-108. doi: 10.1016/j.gaitpost.2016.08.020. Epub 2016 Aug 26. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D005080 | Exercise Test |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Device |
|
| 8 weeks and 20 weeks |
| Change from Baseline Unified Parkinson's Disease Rating Scale (UPDRS) | 8 weeks and 20 weeks |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |