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| ID | Type | Description | Link |
|---|---|---|---|
| 109/01/13 | Other Identifier | National Medical Ethics Committee of the Republic of Slovenia (NMEC) |
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Drug-drug interactions (DDIs) are common in patients with chronic heart failure (CHF) and their incidence increases with the number of drugs that the patients are prescribed for treatment of their condition. Data bases often detect DDIs that are of high clinical relevance. The investigators have performed this study in order to detect clinically significant DDIs and to diminish their occurrence by sending notification about DDIs to attending physician.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Advice on DDIs | Experimental | Attending physician will be randomly assigned to intervention arm care as usual; in the intervention arm, he/she will receive advice about DDIs between medications prescribed to patients on top of general heart failure advice. |
|
| General advice | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Advice on DDIs | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| To assess the difference in frequency and severity of clinically significant DDIs in control arm and interventional arm between admission and discharge | We will measure the difference in clinically significant DDIs between admission and discharge. The doctors in control group will not receive the advice about DDIs between drugs prescribed to patient, while the doctors in interventional group will. With this will will assess the impact of the advice in the occurence of DDIs between admission and discharge for both groups. | 90 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mitja Lainscak, PhD | Contact | +38642569141 | mitja.lainscak@guest.arnes.si |
| Name | Affiliation | Role |
|---|---|---|
| Mitja Lainscak, PhD | University Clinic Golnik | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Clinic Golnik | Recruiting | Golnik | 4204 | Slovenia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26580349 | Derived | Roblek T, Deticek A, Leskovar B, Suskovic S, Horvat M, Belic A, Mrhar A, Lainscak M. Clinical-pharmacist intervention reduces clinically relevant drug-drug interactions in patients with heart failure: A randomized, double-blind, controlled trial. Int J Cardiol. 2016 Jan 15;203:647-52. doi: 10.1016/j.ijcard.2015.10.206. Epub 2015 Oct 28. |
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