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The purpose of this study is to determine if Enteral Feeding (EN) in patients with a traumatic bowel injury requiring an open abdomen impacts outcomes. Patients who receive EN will be compared to those who remain nil-per-os (NPO). Additionally, an internal study control will be performed by analyzing concurrent injured patients requiring an open abdomen who did not have a bowel injury.
Specific aims:
Hypothesis 1: EN in patients with a traumatic bowel injury requiring an open abdomen improves fascial closure rate compared to patients who remain NPO.
Hypothesis 2: EN in patients with a traumatic bowel injury requiring an open abdomen reduces infectious complications compared to patients who remain NPO.
Hypothesis 3: EN in patients with a traumatic bowel injury requiring an open abdomen have a lower mortality rate compared to patients who remain NPO.
Fascial closure is determine by the primary physician and should be recorded in the operative record. This record will be accessed to determine if this variable is accomplished. Additionally, any dehiscence complication will be recorded (which would impact the long-term fascial closure rate). Infectious complications (abscess, pneumonia, etc) will be adjudicated by the primary clinician and any record of this in the patient chart will be recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bowel injury, NPO | Patients with bowel injury who remain nil-per-os (fed nothing) | ||
| bowel injury, EN | Patients with bowel injury who are fed by enteral nutrition (EN) | ||
| no bowel injury, NPO | Patients without bowl injury who remain nil-per-os (fed nothing) | ||
| no bowel injury, EN | Patient without bowl injury who are fed by enteral nutrition (EN) |
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| Measure | Description | Time Frame |
|---|---|---|
| fascial closure rate | physical exam will document fascial closure | participants will be followed for their hospital stay, which is on average expected to be 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| mortality | subject mortality status | participants will be followed for their hospital stay, which is on average expected to be 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| infectious complications | physical exam and imaging will be reviewed to assess infections | participants will be followed for their hospital stay, which is on average expected to be 1 month |
Inclusion Criteria:
Exclusion Criteria:
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All patients requiring an open abdomen following trauma will be prospectively followed.
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| Name | Affiliation | Role |
|---|---|---|
| Clay Cothren Burlew, MD | Denver Health and Hospital Authority | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Denver Health Medical Center | Denver | Colorado | 80204 | United States |
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| ID | Term |
|---|---|
| D000007 | Abdominal Injuries |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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