Prevention of Ovarian Cancer in Women Participating in Mammography

Prevention of Ovarian Cancer in Women Participating in Mammography

The primary purpose of this study is to evaluate the effect of systematic identification and genetic counseling referral on rates of bilateral salpingo-oophorectomy (surgery to remove both fallopian tubes and ovaries) in women having mammograms at Swedish Medical Center in Seattle, WA.

Inclusion Criteria:

• Prior mammogram at Swedish Medical Center
• Willing and able to provide informed consent, primary physician information, and complete study questionnaires
• Must meet at least ONE of the following criteria:
• personal history of breast cancer diagnosed before age 50
• personal history of bilateral breast cancer at any age
• 1 or more first degree relatives with breast cancer diagnosed before age 50
• 3 or more first or second degree relatives with breast cancer at any age
• 2 second degree relatives with breast cancer diagnosed before age 50
• A male relative with breast cancer at any age
• Ashkenazi Jewish with any family history of breast or ovarian cancer
• 1 first or second degree relative with ovarian cancer AND 1 first or second degree relative with breast cancer at any age
• 2 first degree relatives with ovarian cancer or 2 second degree relatives with ovarian cancer or 1 first and 1 second degree relative with ovarian cancer.
• A first degree relative with both breast and ovarian cancer (2 primaries in the same person)
• Personal history of positive genetic test result for any of the following genes: BRCA1, BRCA2, HNPCC, or P53
• Family history of a positive genetic test result for any of the following genes: BRCA1, BRCA2 or HNPCC

Exclusion Criteria:

• Previous diagnosis of ovarian cancer
• Prior bilateral-salpingo oophorectomy
• Had a negative genetic test result for a known family genetic mutation