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| ID | Type | Description | Link |
|---|---|---|---|
| Dnr 2011-52-31M | Other Identifier | Regional Ethics Board in Umeå |
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Idiopathic normal pressure hydrocephalus (INPH) is a treatable and a common disease of the elderly. The overall objective of this work is to describe cardio- and cerebrovascular risk factors and vascular disease in shunted INPH-patients compared to an age- and sex matched elderly population, as well as the impact of vascular risk factors and vascular co-morbidity on clinical symptoms and outcome of surgery in INPH-patients. The hypothesis is that INPH-patients have a higher level of vascular risk factors and subclinical organ damage than a normal elderly population, and that the higher the level of existing vascular risk factors, the more severe the symptoms of the hydrocephalic disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Shunted patients with INPH | Cases: Patients with normal pressure hydrocephalus who have underwent surgery. Controls: Sex- and age-matched community based controls. | ||
| Populationbased elderly. | A group of populationbased elderly, matched according to age and sex to the patients with INPH. Vascular risk factors studied. |
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| Measure | Description | Time Frame |
|---|---|---|
| Differences in bloodpressure between INPH-patients and a sex- and agematched community based population | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than two weeks, not longer than 6 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of Life in INPH-patients compared to a sex- and age-matched population. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. |
| Measure | Description | Time Frame |
|---|---|---|
| Differences between INPH-patients and community based controls regarding smoking. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. |
Inclusion Criteria:
Exclusion Criteria:
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Cases are all INPH-patients who underwent surgery 2008-2010 and are registered in the Swedish National Register of Hydrocephalus. Controls were found in the Swedish population indox of Umeå, and were indivdually matched to cases according to age and sex.
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| Name | Affiliation | Role |
|---|---|---|
| Jan Malm, MD, PhD | Umeå University, Departement of Pharmacology and Clinical Neuroscience | Study Director |
| Hanna Israelsson, MD, PhD-stud | Umeå University, Departement of Pharmacology and Clinical Neuroscience | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Umeå University, Umeå University Hospital, Departement of Pharmacology and Clinical Neuroscience | Umeå | Västerbotten County | 901 87 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35901765 | Derived | Eklund SA, Israelsson H, Carlberg B, Malm J. Vascular risk profiles for predicting outcome and long-term mortality in patients with idiopathic normal pressure hydrocephalus: comparison of clinical decision support tools. J Neurosurg. 2022 Jun 10;138(2):476-482. doi: 10.3171/2022.4.JNS22125. Print 2023 Feb 1. |
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| ID | Term |
|---|---|
| D006850 | Hydrocephalus, Normal Pressure |
| D014652 | Vascular Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| ID | Term |
|---|---|
| D006849 | Hydrocephalus |
| D002318 | Cardiovascular Diseases |
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| More than 2 weeks, not longer than 6 months. |
| More than two weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding waist-to-hip ratio. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding dietary risk score. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not more than 6 months. |
| Differences between INPH-patients and community based controls regarding physical activity. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding diabetes mellitus. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding alcohol intake. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding psychosocial factors. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding cardiac causes. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than two weeks, not longer than 6 weeks. |
| Differences between INPH-patients and community based controls regarding ratio of apolipoprotein B to A1. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding activities of daily life (ADL). | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding frequency, severity and fear of falling. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding headache. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding epilepsy. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |
| Differences between INPH-patients and community based controls regarding kidney function. | Enrollment of participants 2010-2012. First, all participants complete a questionnaire, second they go to their local health care center or nearby hospital for measurements and blood samples. The visit at the health care center/hospital is within a couple of months. Participants are not followed further (cross-sectional study). Analyses performed 2013-2014. First results approximately reported in the end of 2013. | More than 2 weeks, not longer than 6 months. |