The purpose of this study is to determine whether the peripheral balloon dilatation catheter (trade name: Iris) is safe an effective in PTA procedure.

Inclusion Criteria:

• Age: 18 yrs - 80 yrs.
• patients with iliac and / or femoral artery atherosclerotic lesions
• Rutherford grade of 1-5;
• Target lesion stenosis≥70% (visual estimation) (proportion of Trans-Atlantic Inter-Society Consensus(TASC) B, C and D grade lesions not less than 60% )
• Patients being able to understand the purpose of the test, and being volunteered to participate in and sign the informed consent.

Exclusion Criteria:

• Patients not suitable for receiving interventional surgeries of lower limb arteries for treatment;
• Patients require intervention of lesions besides unilateral iliac and femoral artery lesions at the same time;
• Patients have been involved in clinical trials of other drugs or medical devices within the past three months;
• Patient is unable or unwilling to participate in this trial;
• Patients with serious heart and brain, liver and other vital organs failure;
• Patients with life expectancy less than 6 months;
• Pregnant women.