Multiple Ascending Doses Study of CG400549

Evaluation of Safety, Tolerability and Pharmacokinetic Characteristics of Multiple Ascending Doses of CG400549 in Healthy Volunteers

The purpose of this study is to investigate the safety and tolerability of 3 multiple and escalating dose regimens of CG400549 administered orally in healthy volunteers.

This is a Phase 1, 3 cohorts study consisting of a randomised, double-blind, and placebo-controlled design.

Inclusion Criteria:

• Age:18-55 years, inclusive
• Body Mass Index :19-30 kg/m2, inclusive
• Sex:male
• Other criteria:healthy; non-smoking or smoking ≤ 10 cigarettes/day

Exclusion Criteria:

• Evidence of clinically relevant pathology
• History of bacterial or viral infection requiring treatment with antibiotics or antivirals within 1 month of study
• Presence or history of esophageal or gastroduodenal ulceration within 1 month before screening.