interim analysis : discontinuation for efficacy of the intervention

The purpose of this study is to evaluate the efficacy of the implementation of an educational program on adherence to capecitabine alone or in combination to lapatinib.

200 subjects who meet the inclusion/exclusion criteria treated by capecitabine +/- lapatinib, will be enrolled into the study. Adherence to treatment of all subjects will be assessed during a first adherence evaluation period of 3 cycles in order to identify patients who need educational intervention(non adherent patients). Only nonadherent patients (adherence rate < 80%) will receive an education intervention. During the educational program, the efficacy of the implementation of an educational program on adherence to capecitabine alone or in combination to lapatinib will be evaluated for the 6 subsequent cycles.

Inclusion Criteria:

• Age> 18 years
• histologically confirmed breast cancer or colorectal cancer
• Patient starting oral treatment : capecitabine alone or in combination with lapatinib (can be included before the first cycle or during the first 2 cycles).
• Volunteer to participate in the study.
• ambulatory treated patient
• Able to read, write and understand French.
• Subject who accept to use MEMS monitors to automatically compile their drug dosing histories
• Written informed consent

Exclusion Criteria:

• more than 3 metastatic chemotherapies
• any severe concomitant condition which makes it undesirable for the patient to participate in the study or which would jeopardize adherence with trial protocol