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The purpose of this study is to determine whether one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) induces immunological memory in asplenic adults and whether previously administered immunizations with the 23-valent polysaccharide pneumococcal vaccine influence the cellular immune response to PCV13 in this group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PCV13 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PCV13 | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| immunoglobulin G (IgG) B memory cell response one month post vaccination (measured by ELISpot) | One month post-PCV13 | |
| immunoglobulin M (IgM) B memory cell response one month post vaccination (measured by ELISpot) | one month post PCV13 |
| Measure | Description | Time Frame |
|---|---|---|
| Maintenance of B memory cells three years after PCV13 vaccination | three years after study vaccination |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 'Aghia Sophia' Children's Hospital | Athens | Attica | 11527 | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30683996 | Derived | Papadatou I, Lagousi T, Kattamis A, Spoulou V. Antibody persistence 5 years after a 13-valent pneumococcal conjugate vaccine in asplenic patients with beta-thalassemia: assessing the need for booster. Ann Hematol. 2019 Mar;98(3):775-779. doi: 10.1007/s00277-019-03615-z. Epub 2019 Jan 25. | |
| 24879786 | Derived |
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| Papadatou I, Piperi C, Alexandraki K, Kattamis A, Theodoridou M, Spoulou V. Antigen-specific B-cell response to 13-valent pneumococcal conjugate vaccine in asplenic individuals with beta-thalassemia previously immunized with 23-valent pneumococcal polysaccharide vaccine. Clin Infect Dis. 2014 Sep 15;59(6):862-5. doi: 10.1093/cid/ciu409. Epub 2014 May 30. |