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The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and body composition in MS patients.
It is assumed that the the above mentioned clinical parameters will improve due to physical exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Combined exercise | Experimental | 12 weeks combined exercise programme (supervised) |
|
| High intensity interval training | Experimental | 12 weeks high intensity interval exercise programme (supervised) |
|
| Control | No Intervention | sedentary/habitual lifestyle |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training | Behavioral |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| insulin sensitivity (insulin profile) | glucose and insulin concentration measurements in blood | change from baseline to 12 weeks |
| muscle contractile properties | measurements of cross sectional area and fiber distribution in muscle fibers of the m. vastus lateralis + measurements of enzymatic reactions, ATP, glycogen, ... | from baseline to 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| muscle strength of knee extensor/flexor | by means of an isokinetic dynamometer the muscle strength and endurance will be measured | change from baseline to 12 weeks |
| aerobic capacity | by means of a submaximal endurance test (ergometer) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Inez Wens, M.Sc. | Reval/Biomed, Hasselt University | Principal Investigator |
| Bert Opt Eijnde, Ph.D | Reval/Biomed, Hasselt University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Reval | Diepenbeek | 3590 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26418222 | Derived | Wens I, Dalgas U, Vandenabeele F, Grevendonk L, Verboven K, Hansen D, Eijnde BO. High Intensity Exercise in Multiple Sclerosis: Effects on Muscle Contractile Characteristics and Exercise Capacity, a Randomised Controlled Trial. PLoS One. 2015 Sep 29;10(9):e0133697. doi: 10.1371/journal.pone.0133697. eCollection 2015. | |
| 25666356 | Derived |
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| change from baseline to 12 weeks |
| cytokine profile | measurements of blood cytokine levels | change from baseline to 12 weeks |
| Self-reported measures | The self-reported measures contains some questionnaires | Change from baseline to 12 weeks |
| body composition | Weight, body fat% and lean tissue% will be assessed by means of a DEXA scan | Change from baseline to 12 weeks |
| Hansen D, Wens I, Vandenabeele F, Verboven K, Eijnde BO. Altered signaling for mitochondrial and myofibrillar biogenesis in skeletal muscles of patients with multiple sclerosis. Transl Res. 2015 Jul;166(1):70-9. doi: 10.1016/j.trsl.2015.01.006. Epub 2015 Jan 20. |
| 25264868 | Derived | Wens I, Dalgas U, Vandenabeele F, Krekels M, Grevendonk L, Eijnde BO. Multiple sclerosis affects skeletal muscle characteristics. PLoS One. 2014 Sep 29;9(9):e108158. doi: 10.1371/journal.pone.0108158. eCollection 2014. |
| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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