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The present study assesses whether language functions in patients with residual post-stroke aphasia can be improved by transcranial direct current stimulation administered to the primary motor cortex in the language dominant (left) hemisphere.
Patients will participate in two tDCS sessions (atDCS; sham) in a cross-over within subjects design. tDCS or placebo will be administered during simulatneous fMRI to assess neural signatures of the stimulation. Order of stimulation will be counterbalanced between subjects
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| anodal tDCS | Experimental | atDCS will be administered for 20 minutes with 1 milliampere (1 mA) to the left primary hand motor cortex |
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| sham tDCS | Sham Comparator | sham tDCS will be administered to the left primary hand motor cortex |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| atDCS | Device | atDCS will be delivered with a constant current of 1 mA during simultaneous resting-state (RS) and task-related (picture naming) functional magnetic resonance imaging (fMRI). The current will be turned on prior to the RS-fMRI scan and continues for 20 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Response latency during picture naming task (max. 80) | Subjects are assessed in a cross-over design. The primary outcome measure will be assessed twice in each subject, either during placebo ("sham) stimulation or active (anodal) stimulation with transcranial direct current stimulation. Order of stimulation will be counterbalanced across the group. | Change in response latency between assessment 1 (week 1) and assessment 2 (week 2), assessments 1 and 2 are seperated by one week |
| Measure | Description | Time Frame |
|---|---|---|
| Change in neural activity measured by functional magnetic resonance imaging | Change in fMRI activity between Assessment 1 (week 1) and Assessment 2 (week 2), assessments 1 and 2 are seperated by one week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Robert Darkow, MSc | Contact | +49 30 450 560 | 395 | robert.darkow@charite.de |
| Name | Affiliation | Role |
|---|---|---|
| Marcus Meinzer, PhD | Charite, University Medicine, Neurology | Principal Investigator |
| Agnes Flöel, MD | Charite, University Medicine, Neurology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charite, University Medicine, Dept. of Neurology | Recruiting | Berlin | State of Berlin | 10117 | Germany |
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| sham tDCS | Device | During sham the current will be increeased and decreased in a ramp-like fashion (10 sec) |
|