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| ID | Type | Description | Link |
|---|---|---|---|
| KI-MUHAS1 | Registry Identifier | RDT-ClearTZ1 |
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| Name | Class |
|---|---|
| Muhimbili University of Health and Allied Sciences | OTHER |
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The aim of the study was to follow clearance of malaria infections and detection of new malaria episodes after initiation of antimalarial treatment in Tanzanian children. For this purpose the investigators used five diagnostic tools, 2 Rapid Diagnostic tests based on Histidine Rich Protein 2(HRP2) and Lactate dehydrogenase(LDH), 2 microscopical methods and one polymerase chain reaction (PCR). The investigators followed the 53 enrolled children during 42 days.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| children with malaria | Tanzanian children between 6-59 months with an uncomplicated P.falciparum monoinfection, followed after arthemeter-lumefantrine treatment according to national treatment guidelines |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HRP2 and LDH based rapid diagnostic tests for P.falciparum | Device |
|
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| Measure | Description | Time Frame |
|---|---|---|
| Clearance time with five diagnostic tests | Children were followed up on 9 occasions until day 42. Mean and median time until clearance after initiation of arthemeter-lumefantrine treatment was measured for HRP2 based Rapid diagnostic tests, LDH-based Rapid diagnostic tests, Giemsa and Acridine Orange stained microscopy and real-time PCR. | 2009 June to 2012 May (up to day 42) |
| Detection of recurrent infection with HRP2 and LDH-based Rapid diagnostic tests during follow up | Ability to detect recurrent malaria infection with the HRP2 and LDH-Rapid diagnostic tests during the 42 days of follow up was studied through comparing them with three other diagnostic tests. | 2009 June to 2012 May (up to day 42) |
| Measure | Description | Time Frame |
|---|---|---|
| Efficiency of P.falciparum specific rapid diagnostic tests | Efficiency of two rapid diagnostic tests based on two different antigens for diagnosis and treatment follow up among children <5 years in a moderately high endemic area was determined. Specificity and false positivity rate for HRP2 and LDH based rapid diagnostic tests are calculated against Giemsa stained microscopy and PCR. | 2009 June to 2012 May (up to day 42) |
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Inclusion Criteria:
Exclusion Criteria:
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Children with fever visiting primary health care units in malaria endemic area
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| Name | Affiliation | Role |
|---|---|---|
| Anders Björkman, Professor | Karolinska Institutet | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mlandizi Health Centre and Fukayosi dispencary | Dar es Salaam | Kibaha and Bagamoyo District | Tanzania | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24079306 | Derived | Aydin-Schmidt B, Mubi M, Morris U, Petzold M, Ngasala BE, Premji Z, Bjorkman A, Martensson A. Usefulness of Plasmodium falciparum-specific rapid diagnostic tests for assessment of parasite clearance and detection of recurrent infections after artemisinin-based combination therapy. Malar J. 2013 Oct 1;12:349. doi: 10.1186/1475-2875-12-349. |
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| ID | Term |
|---|---|
| D016778 | Malaria, Falciparum |
| D008288 | Malaria |
| D004194 | Disease |
| ID | Term |
|---|---|
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000096724 | Mosquito-Borne Diseases |
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Whole capillary blood collected for Rapid Diagnostic tests, microscopy and PCR
| Muhimbili University of Health Allied Science |
| Dar es Salaam |
| 65001 |
| Tanzania |
| D000079426 |
| Vector Borne Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |