Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Usefulness of Flospan as a premedication for colonoscopy: A randomized double-blind controlled trial
Cimetropium bromide is premedication of colonoscopy. However, it is contraindication for some diseases; benign prostatic hyperplasia(BPH) or other obstructive uropathy, intestinal obstruction, pyloric stenosis, glaucoma, myasthenia gravis, megacolon, paralytic ileus. In this cases, Flospan (phloroglucin) is effective alternative drug. So our research was to compare the effects of these two drugs.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phloroglucin & Placebo | Experimental | Phloroglucin 20ml before examination & Placebo 1ml before examination |
|
| Cimetropium bromide & Placebo | Experimental | Cimetropium bromide 1ml before examination & Placebo 20ml before examination |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phloroglucin | Drug | Premedication of colonoscopy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Non inferiority of phloroglucin to cimetropium bromide | Comparing the two groups of time of examination, frequency of peristalsis, Scoring for the experimenter and the subject of the inspection feedback, double-blind setting. | Up to ten months |
| Measure | Description | Time Frame |
|---|---|---|
| Total diagnostic colonoscopy exam time | 1 year | |
| Evaluation of practitioners | Colonic motility and test difficulty | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Bowel cleansing status | 1 year | |
| Heart rate, respiratory rate, oxygen saturation, blood pressure | 1 year |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kee Myung Lee, M.D., Ph.D. | Contact | 82-31-219-6939 | lkm5104@ajou.ac.kr | |
| Sun Gyo Lim, M.D. | Contact | 82-31-219-6939 | mdlsk75@hanmail.net |
| Name | Affiliation | Role |
|---|---|---|
| Kee Myung Lee, M.D., Ph.D. | Ajou University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ajou University Hospital | Recruiting | Suwon | 443-721 | South Korea |
Not provided
| ID | Term |
|---|---|
| D010696 | Phloroglucinol |
| C016859 | cimetropium |
| D018680 | Cholinergic Antagonists |
| D003113 | Colonoscopy |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Cimetropium bromide | Drug | Premedication of colonoscopy |
|
|
| Colonoscopy | Procedure | Diagnostic examination of colon |
|
|
| Placebo | Drug | Placebo for double-blind study These are harmless to the human body, and are composed of saline solution without drug efficacy. |
|
| Evaluation of subjects |
The degree of discomfort after test |
| 1 year |
| Peristalsis time of transverse colon | Total peristalsis time of transverse colon for two minutes | 1 year |
| Total dose and times of sedatives for pain control | Total dose and times of sedatives (midazolam, propofol) for pain control | 1 year |
| Time of cecal intubation | Total time of colonoscope intubation from anus to cecum | 1 year |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D018678 | Cholinergic Agents |
| D018377 | Neurotransmitter Agents |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D045505 | Physiological Effects of Drugs |
| D016099 | Endoscopy, Gastrointestinal |
| D016145 | Endoscopy, Digestive System |
| D003938 | Diagnostic Techniques, Digestive System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004724 | Endoscopy |
| D003949 | Diagnostic Techniques, Surgical |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019060 | Minimally Invasive Surgical Procedures |