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The purpose of this non interventional research is to set up a French database, initially for 3 years, of patients suffering from refractory chronic headache disorders (chronic migraine, cluster headache, chronic paroxysmal hemicranias, SUNCT syndrome, hemicrania continua, cervicogenic headache disorders), and treated by occipital nerves stimulation.
Every team using this neuromodulation approach in France is likely to participate in the network.
Fifty patients a year are expected. They will be informed about data which are collected and why they are collected.
The data will come from medical files and questionnaires filling out by the patients. The data will be collected on a case report form adapted to each refractory chronic headache disorder. The case report form pages will be faxed to the coordinating team who will enter the data in the database and analyse the data in a descriptive manner.
These data are social and demographic data, medical data (headache features, headache functional and emotional impact, medications, and concomitant medical conditions), technical data (kind of electrodes and implantable pulse generator used, stimulation parameters chosen), and safety data.
This research should provide an update on practices, an evaluation of the efficacy and long term safety of occipital nerves stimulation, and perhaps help in identifying response predictive factors to this neuromodulation approach.
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| Measure | Description | Time Frame |
|---|---|---|
| observation of a disease or medical condition under normal conditions | social and demographic data, medical data (headache features, headache functional and emotional impact, medications, and concomitant medical conditions), technical data (kind of electrodes and implantable pulse generator used, stimulation parameters chosen), and safety data. | at each visit (up to 4 years) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients suffering from refractory chronic headache disorders (chronic migraine, cluster headache, chronic paroxysmal hemicranias, SUNCT syndrome (Short-lasting Unilateral Neuralgiform headache attacks with Conjunctival injection and Tearing), hemicrania continua, cervicogenic headache disorders) according to ICHD-II
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| Name | Affiliation | Role |
|---|---|---|
| Michel LANTERI-MINET | CHU de Nice département d'évaluation et traitement de la Douleur | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopitaux Civil de Colmar | Colmar | Haut-rhin | 68024 | France | ||
| Clermont Ferrand CHU |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41826825 | Derived | Fontaine D, Fabre R, Leplus A, Donnet A, Regis J, Balossier A, Lucas C, Buisset N, Raoul S, Derrey S, Jarraya B, Creach C, Chabardes S, Voirin J, Colnat-Coulbois S, Caire F, Rigoard P, Demarquay G, Simon E, Lanteri-Minet M. Predictive factors of effectiveness of occipital nerve stimulation for chronic cluster headache: data from for the French ONS registry. J Headache Pain. 2026 Mar 13;27(1):114. doi: 10.1186/s10194-026-02319-w. | |
| 41739034 |
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| Clermont-Ferrand |
| 63003 |
| France |
| Annecy Genevois CHU | Épagny | 74370 | France |
| Grenoble CHU | Grenoble | 38043 | France |
| Lille CHU | Lille | 59037 | France |
| Limoges CHU | Limoges | 87000 | France |
| HCL | Lyon | 69229 | France |
| APHM | Marseille | 13354 | France |
| Nancy CHU | Nancy | 54035 | France |
| Nantes CHU | Nantes | 44093 | France |
| Département d'Evaluation et Traitement de la Douleur | Nice | 06000 | France |
| AP-HP Lariboisière | Paris | 75184 | France |
| Adolphe de Rothschild Foundation | Paris | 75940 | France |
| Poitiers CHU | Poitiers | 86021 | France |
| Saint Etienne CHU | Saint-Etienne | 42055 | France |
| Foch Hospital | Suresnes | 92150 | France |
| Derived |
| Messaoudi S, Leplus A, Donnet A, Regis J, Balossier A, Raoul S, Demarquay G, Simon E, Moisset X, Sinardet D, Voirin J, Colnat-Coulbois S, Lanteri-Minet M, Fontaine D. Decreasing the Risk of Lead Migration in Occipital Nerve Stimulation for Cluster Headache Using Dedicated Leads. Neuromodulation. 2026 Feb 25:S1094-7159(26)00015-2. doi: 10.1016/j.neurom.2026.01.009. Online ahead of print. |
| 35688701 | Derived | Balossier A, Donnet A, Regis J, Leplus A, Lanteri-Minet M, Fontaine D. Occipital Nerve Stimulation for Recurrent Trigeminal Neuralgia Without Occipital Pain. Neuromodulation. 2023 Dec;26(8):1795-1801. doi: 10.1016/j.neurom.2022.03.012. Epub 2022 Jun 7. |
| 27697849 | Derived | Fontaine D, Blond S, Lucas C, Regis J, Donnet A, Derrey S, Guegan-Massardier E, Jarraya B, Dang-Vu B, Bourdain F, Valade D, Roos C, Creach C, Chabardes S, Giraud P, Voirin J, Bloch J, Rocca A, Colnat-Coulbois S, Caire F, Roger C, Romettino S, Lanteri-Minet M. Occipital nerve stimulation improves the quality of life in medically-intractable chronic cluster headache: Results of an observational prospective study. Cephalalgia. 2017 Oct;37(12):1173-1179. doi: 10.1177/0333102416673206. Epub 2016 Oct 3. |
| ID | Term |
|---|---|
| D020773 | Headache Disorders |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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