Endometrial Scratching in In Vitro Fertilization Cycles With Oocyte Donation

Randomized Prospective Study of Endometrial Injury in In Vitro Fertilization Cycles With Oocyte Donation

This study is designed to evaluate the potential benefit in pregnancy rates produced by an endometrial scratching made in an IVF cycle prior to embryo transfer in patients with donated oocytes.

This is a randomized, comparative, prospective, double Blind study.

The First stage of this study consists of revising the patients medical records to identify possible candidates. Patients indicated are randomized into two groups: experimental and control. They are followed up to 12 week of pregnancy.

Inclusion Criteria:

• Do IVF cycle with donor eggs
• Will adjust to protocol for the study.
• Have signed informed consent

Exclusion Criteria:

• Clinically significant systemic disease, hypothalamic or pituitary tumors
• ovarian, uterine or breast cancer
• hormonal abnormalities and / or medical , biochemistry, hematology pathology, which might interfere with gonadotropin treatment.
• known positivity for human immunodeficiency virus (HIV), hepatitis C or B virus (HCV / HBV) of the candidate or her partner.
• Uterine Factor(submucosal fibroids, intramural fibroids> 4 cm)
• Hydrosalpinx
• Patients receiving immune treatment
• Positive Diagnosis Thrombophilia
• preimplantation genetic diagnosis needed
• In case of using marital sperm are excluded the following patients:Altered male karyotype, Altered Meiosis in testicular biopsy, Altered FISH, sperm Fragmentation> 45%
• Pregnancy contraindication
• Known allergy to preparations containing estrogens or any of its excipients.
• Simultaneous participation in another clinical trial with medication.
• Do not want or can not adjust to study protocol.