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| Name | Class |
|---|---|
| Lundbeck Foundation | OTHER |
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The purpose of this study is to investigate subjective sleep quality and fatigue during and after Acute uncomplicated diverticulitis assessed by questionnaires and a sleep-diary. The investigators hypothesis is that subjective sleep and fatigue are correlated with the inflammatory activities.
An increasing number of experimental studies have showed that inflammation can induce disturbances in sleep architecture, mediated by cytokines. some studies showed that cytokines also induce daytime fatigue. In this study the investigators aim to describe the patient experiences of sleep and fatigue during the acute inflammation and the recovery, and the investigators seek to exam the correlation of fatigue with Polysomnography-measured night sleep and cytokine levels in plasma.
Following methods will be applied
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| acute uncomplicated diverticulitis | CT-verified acute uncomplicated diverticulitis managed by antibiotics |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in Sleep quality during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day) |
| 1st-10th day and 14th, 21st, 30th day following the admission |
| Changes in Sleepiness during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day) | Sleepiness measured by Karolinska Sleepiness Scale at given time frame | 1st-10th day and 14th, 21st, 30th day following the admission |
| Changes in fatigue during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day) |
| 1st-10th day and 14th, 21st, 30th day following the admission |
| Changes in general well-being during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day) | general well being measured on VAS | 1st-10th day and 14th, 21st, 30th day following the admission |
| Changes in pain during acute uncomplicated diverticulitis from baseline score at remission (14th, 21st and 30th day) | Pain measured on VAS | 1st-10th day and 14th, 21st, 30th day following the admission |
| Measure | Description | Time Frame |
|---|---|---|
| accuracy of sleep diary compared to actigraph in measuring sleep data | Sleep quantity registered by the sleep diary compared with actigraph measured sleep quantity at given time frame | 1st-10th day and 14th, 21st, 30th day following the admission |
| accuracy of sleep diary compared to Polysomnography (PSG) in measuring sleep data |
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Inclusion Criteria:
Exclusion Criteria:
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16 x Acute uncomplicated diverticulitis (Hansen and stock stage 1) patients aged 18-75 years managed by antibiotic treatment at Herlev Hospital.
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| Name | Affiliation | Role |
|---|---|---|
| Ismail Gögenur, M.D. | University of Copenhagen, Herlev Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department D, Herlev Hospital | Herlev | Copenhagen | 2730 | Denmark |
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plasma
Sleep quantity registered by the sleep diary compared with PSG measured sleep quantity at given time frame |
| 1st-2nd day and 30th day following the admission |
| correlation between fatigue and level of cytokines in patient's plasma | Investigator seek to find correlations between levels of IL-2, IL-6, TNF-alpha, CRP, Leucocytes and subjective fatigue measured by VAS and a 10 points scale. | 1st and 2nd and 30th day following the admission |
| correlation between pain and level of cytokines in patient's plasma | Investigator seek to find correlations between levels of IL-2, IL-6, TNF-alpha, CRP, Leucocytes and subjective pain measured by VAS. | 1st and 2nd and 30th day following the admission |
| correlation between sleepiness and level of cytokines in patient's plasma | Investigator seek to find correlations between levels of IL-2, IL-6, TNF-alpha, CRP, Leucocytes and subjective sleepiness measured by Karolinsk Sleepiness Scale | 1st and 2nd and 30th day following the admission |
| correlation between general well-being and level of cytokines in patient's plasma | Investigator seek to find correlations between levels of IL-2, IL-6, TNF-alpha, CRP, Leucocytes and general well-being measured by VAS | 1st and 2nd and 30th day following the admission |