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The beneficial effect of daytime sleep on memory consolidation has been shown in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during daytime SWS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SHAM stimulation | Experimental | SHAM stimulation during periods of Slow Wave Sleep |
|
| 0,75 Hz stimulation | Experimental | slow transcranial oscillating stimulation (~0,75Hz) during periods of Slow Wave Sleep |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| brain stimulation | Device | oscillating direct current brain stimulation |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS | Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Amount of Slow wave Sleep | 1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS. | 4 weeks |
| 2. sleep spindles | 2. Spindle activity during sleep indicated via several spindle parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Flöel, Professor | Charite Universitätsmedizin Berlin - Neurologie | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charite CCM Neurologie Berlin | Berlin | State of Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17086200 | Background | Marshall L, Helgadottir H, Molle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. doi: 10.1038/nature05278. Epub 2006 Nov 5. | |
| 20046194 | Background | Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4. |
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| ID | Term |
|---|---|
| D046690 | Deep Brain Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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| no stimulation |
| Device |
sham Stimulation |
|
| 4 weeks |
| 3. EEG-correlates | 3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task). | 4 weeks |
| 4. further memory systems | 4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS. | 4 weeks |
| 18554731 | Background | Mednick SC, Cai DJ, Kanady J, Drummond SP. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res. 2008 Nov 3;193(1):79-86. doi: 10.1016/j.bbr.2008.04.028. Epub 2008 May 8. |
| 21377092 | Background | Mander BA, Santhanam S, Saletin JM, Walker MP. Wake deterioration and sleep restoration of human learning. Curr Biol. 2011 Mar 8;21(5):R183-4. doi: 10.1016/j.cub.2011.01.019. No abstract available. |
| 12819785 | Background | Mednick S, Nakayama K, Stickgold R. Sleep-dependent learning: a nap is as good as a night. Nat Neurosci. 2003 Jul;6(7):697-8. doi: 10.1038/nn1078. |
| 33406266 | Derived | Ladenbauer J, Ladenbauer J, Kulzow N, Floel A. Memory-relevant nap sleep physiology in healthy and pathological aging. Sleep. 2021 Jul 9;44(7):zsab002. doi: 10.1093/sleep/zsab002. |