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| Name | Class |
|---|---|
| Lundbeck Foundation | OTHER |
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The purpose of this study is to investigate sleep disturbances during Acute uncomplicated diverticulitis by polysomnography. The investigators hypothesis is the inflammation causes REM(rapid eye movement)-sleep reduction and this is correlated with plasma cytokine levels.
An increasing number of experimental studies have showed that inflammation can induce disturbances in sleep architecture, mediated by cytokines. Sleep is important both in health and disease processes and can affect recovery, morbidity and mortality.
Studies have been done on sleep disturbances after major and minor GI-surgery but never in relation to none surgical inflammatory diseases, namely acute diverticulitis.
This study will investigate sleep architecture by Polysomnography and inflammation by levels of pro inflammatory cytokines in plasma.
Following methods will be applied
Device: Polysomnograph - Embla Titanium (Natus Medical Incorporated, USA)
Procedure: Plasma cytokines (IL-2, IL-6 and TNF(tumor necrosis factor-alfa)
Procedure: Plasma CRP(C reactive protein) and leukocytes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| acute uncomplicated diverticulitis | CT-verified acute uncomplicated diverticulitis managed by antibiotics |
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| Measure | Description | Time Frame |
|---|---|---|
| change in Sleep architecture during acute uncomplicated diverticulitis from baseline at the remission (30th day) | Sleep architecture measured by Polysomnography (awake, stadium I-IV, REM sleep, sleep latency, awakenings) | 1st, 2nd and 30th nights following the admission |
| change in cytokine levels in plasma during the acute uncomplicated diverticulitis from baseline levels at remission | the Blood sample is taken prior to night sleep; Cytokines are measured by commercial ELISA-kits | 1st, 2nd and 30th nights following the admission |
| change in CRP level in plasma during the acute uncomplicated diverticulitis from baseline levels at remission | the Blood sample is taken prior to night sleep; CRP is measured by standardized conventional method | 1st, 2nd and 30th nights following the admission |
| change in leucocyte level in plasma during the acute uncomplicated diverticulitis from baseline levels at remission | the Blood sample is taken prior to night sleep; Leucocyte is measured by standardized conventional method | 1st, 2nd and 30th nights following the admission |
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Inclusion Criteria:
Exclusion Criteria:
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16 x Acute uncomplicated diverticulitis (Hansen and stock stage 1) patients aged 18-75 years managed by antibiotic treatment at Herlev Hospital.
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| Name | Affiliation | Role |
|---|---|---|
| Ismail Gögenur, M.D. | University of Copenhagen, Herlev Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department D, Herlev Hospital | Herlev | Copenhagen | 2730 | Denmark |
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plasma