Effect of Sodium Bicarbonate on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass (OPCAB)

In this single-site, randomized, controlled and double-blind clinical trial, the investigators evaluate the effect of sodium bicarbonate on prevention of acute kidney injury in high risk patients undergoing off pump coronary bypass surgery.

Inclusion Criteria:

• Patients older than 20 years
• scheduled for elective coronary artery bypass grafting.
• preoperative estimated glomerular filtration rate (eGFR) : 30 ~ 89 %
• LVEF < 35%
• NYHA class III or IV
• age > 70
• DM
• reoperation

Exclusion Criteria:

• acute renal impairment
• patients who receive dialysis
• patients who receive steroid ( > 10mg/day prednisolon or equivalent)
• hemo-alkalosis
• hypernatremia
• pulmonary edema
• Hemoglobin < 10 mg/dL