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Post operative cognitive dysfunction (POCD) is a well-recognized complication of patients undergoing cardiac surgery. Previous studies reported near-infrared spectroscopy provides information on the occurrence of cerebral desaturation resulted in POCD. But evidence of POCD after general surgery has been lacking. Especially, the prone position is used primarily for surgical access to the posterior spine, if there is any significant lowering of the legs or tilt of the entire table, venous returns may be decrease or augmented accordingly. The purpose of this study was to examine the relationship between POCD and intra-operative cerebral oxygen saturation after spine surgery in elderly patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| regional cerebral oxygen saturation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neurologic and neuropsychologic tests | Other | Cognitive functioning was assessed with the following test: Korean Mini-Mental State Examination (K-MMSE) and visuomotor test of D-LOTCA battery. Regional cerebral oxygen saturation was continuously monitored using the INVOS 5100 (somatics,Troy, MI) with bifrontal placement of two sensors before the induction of the anesthesia until the end of operation. Baseline rSO2 was defined as the average saturation value over a 1 min period before induction of general anesthesia, beginning approximately 3 min after the sensors were applied in supine position. After the induction, baseline prone rSO2 was defined over a 5min period after the change of position. There is no intervention were made according to rSO2 values. Physiologic variables including BIS, PaCO2,PaO2, glucose, electrolyte, hematocrit, HR, MAP, and nasopharyngeal temperature were measured every 1 hours during the surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| K-MMSE |
3-1. immediate postoperative neuropsychological evaluation (postoperative 4th~7th day) 3-2. remote postoperative neuropsychological evaluation (postoperative 1month) 4. Intraoperative | change of K-MMSE from baseine to 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| visuomotor test(D-LOTCA battery) | :Visuomotor test (D-LOTCA battery)
| measuring for visuomotor test during baseline and 1 month |
| Regional cerebral oxymetry monitoring |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine | Seoul | Seoul | 120-752 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| 33022 | Background | Cox PJ, Farmer PB, Jarman M, Kinas RW, Stec WJ. Stereoselectivity in the metabolism of the enantiomers of cyclophosphamide in mice, rats, and rabbits. Drug Metab Dispos. 1978 Nov-Dec;6(6):617-22. No abstract available. |
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|
|
| measuring for Regional cerebral oxymetry monitoring during baseline and 1 month |
| 3405354 | Background | Stolke D, Seifert V. [Early or late operation on the ruptured aneurysm? An analysis based on 356 cases]. Neurochirurgia (Stuttg). 1988 May;31(3):81-7. doi: 10.1055/s-2008-1053907. German. |
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| 15281175 | Background | Should I consider using an insulin pump to take insulin for type 2 diabetes? Johns Hopkins Med Lett Health After 50. 2004 Aug;17(6):8. No abstract available. |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
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