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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01HD075171-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
| Kinshasa School of Public Health | OTHER |
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The goals of the proposed study are to: 1) test whether small, increasing cash payments to HIV-infected pregnant women, on the condition that they attend scheduled clinic visits and receive proposed services, will increase the proportion of women who receive the most effective antiretroviral regimen they are eligible for by the time of delivery, and 2) elucidate factors that facilitate or inhibit the uptake and adherence to the PMTCT cascade, and to what extent the conditional cash payment program addresses these factors.
This intervention will be implemented and evaluated within our well-established PMTCT program in Kinshasa, Democratic Republic of Congo (DRC),
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard of Care | No Intervention | Routine implementation of the national PMTCT guidelines which are an adaptation of the WHO's "Option A" | |
| Conditional Cash Transfer | Experimental | Financial incentive to attend regular clinic visits and receive PMTCT care |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Conditional cash transfer | Behavioral | Eligible women randomized to the intervention group will receive the standard of care plus small and increasing cash payments, on the condition that they attend scheduled clinic visits on time (+/-5days), accept HIV services, deliver in a health facility, and at six weeks postpartum adhere to prescribed infant prophylactic drugs (cotrimoxazole, extended NVP) and provide blood sample for DNA PCR infant early HIV diagnosis. |
| Measure | Description | Time Frame |
|---|---|---|
| proportion of women who were adherent to all conditionalities and received the most effective ARV intervention they were eligible to receive and delivered at an affiliated maternity | At each monthly visit starting at randomization (28 weeks), participants will be evaluated for the following conditionalities:
| 6 weeks postpartum |
| Measure | Description | Time Frame |
|---|---|---|
| Mother to child transmission rate at six weeks and HIV-free survival. | Proportion of HIV-exposed infant who tested positive at 6 week postpartum | 6 weeks post partum |
| HIV-free survival at 18 month. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marcel Yotebieng, MD | Ohio State University | Principal Investigator |
| Emile W Okitolonda, MD | Kinshasa School of Public Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kinshasa School of Public Health | Kinshasa | Kinshasa | Republic of the Congo |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27787342 | Result | Yotebieng M, Moracco KE, Thirumurthy H, Edmonds A, Tabala M, Kawende B, Wenzi LK, Okitolonda EW, Behets F. Conditional Cash Transfers Improve Retention in PMTCT Services by Mitigating the Negative Effect of Not Having Money to Come to the Clinic. J Acquir Immune Defic Syndr. 2017 Feb 1;74(2):150-157. doi: 10.1097/QAI.0000000000001219. | |
| 26847230 | Result | Yotebieng M, Thirumurthy H, Moracco KE, Kawende B, Chalachala JL, Wenzi LK, Ravelomanana NL, Edmonds A, Thompson D, Okitolonda EW, Behets F. Conditional cash transfers and uptake of and retention in prevention of mother-to-child HIV transmission care: a randomised controlled trial. Lancet HIV. 2016 Feb;3(2):e85-93. doi: 10.1016/S2352-3018(15)00247-7. |
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Proportion of children born to HIV+ enrolled mothers who are alive and non infected with HIV
| 18 months porstpartum |
| Proportion of HIV-exposed infants who at their six week visit received extended Nevirapine (NVP) had a DNA PCR test | Proportion of infants born to HIV-infected participants who at 6 weeks postpartum are receiving the extended nevirapine prophylaxis and have been tested for HIV | 6 weeks Postpartum |
| 27819151 | Result | Yotebieng KA, Fokong K, Yotebieng M. Depression, retention in care, and uptake of PMTCT service in Kinshasa, the Democratic Republic of Congo: a prospective cohort. AIDS Care. 2017 Mar;29(3):285-289. doi: 10.1080/09540121.2016.1255708. Epub 2016 Nov 6. |
| 33691667 | Derived | Saleska JL, Turner AN, Gallo MF, Shoben A, Kawende B, Ravelomanana NLR, Thirumurthy H, Yotebieng M. Role of temporal discounting in a conditional cash transfer (CCT) intervention to improve engagement in the prevention of mother-to-child transmission (PMTCT) cascade. BMC Public Health. 2021 Mar 10;21(1):477. doi: 10.1186/s12889-021-10499-0. |