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Guidelines recommend measuring end organ damage and in particular arterial stiffness in patients with hypertension. However, until now it was not possible to measure arterial stiffness with the use of simple methods. Recently, novel and innovative devices offering determination of arterial stiffness and central hemodynamics from simple and non-invasive arm cuff measurements have now become available. This study therefore evaluates the value of non-invasively measured arterial stiffness and central hemodynamics for guiding antihypertensive treatment in selected patient populations (i.e. elderly patients, patients with diabetes mellitus, patients with heart failure, and patients with resistant hypertension).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Elderly patients |
| ||
| Patients with diabetes mellitus |
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| Patients with heart failure |
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| Patients with resistant hypertension |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optimization of blood pressure according to guidelines | Other | There is no specific recommendation for the intervention. The goal of the intervention is an optimization of blood pressure control. The intervention is at the discretion of the physician, but should adhere to guidelines. The intervention may therefore embrace measures such as drug prescriptions or lifestyle interventions. |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial stiffness and central hemodynamics | Non-invasive measurement of arterial stiffness and central hemodynamics with the Tensiomed Arteriograph device | 3 months |
| Cognitive function | Measurement with Mini Mental State Exam and Verbal Recall Test | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Physical function | Measurement with gait speed, hand grip test and physical activity questionnaire | 3 months |
| Orthostatic hypotension and falls | Measurement with blood pressure recordings and structured questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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Patients referred for optimization of antihypertensive treatment to Luzerner Kantonsspital, Switzerland.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Paul Erne, MD | Contact | ++41 41 205 5208 | paul.erne@luks.ch | |
| Andreas W Schoenenberger, MD | Contact | ++41 79 243 6985 | Andreas.Schoenenberger@insel.ch |
| Name | Affiliation | Role |
|---|---|---|
| Paul Erne, MD | Luzerner Kantonsspital | Study Chair |
| Paul Erne, MD | Luzerner Kantonsspital | Principal Investigator |
| Andreas W Schoenenberger, MD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Luzerner Kantonsspital | Recruiting | Lucerne | Canton of Lucerne | CH-6000 | Switzerland |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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|
| 3 months |
| Renal failure | Creatinine measurement | 3 months |
| University of Bern |
| Principal Investigator |