High-Sensitivity Troponin T and Coronary Computed Tomography Angiography for Rapid Diagnosis of Emergency Chest Pain

High-Sensitivity Troponin T and Coronary Computed Tomography Angiography for Rapid Diagnosis of Emergency Chest Pain: a Randomized Controlled Study

• The purpose of this study is to determine the efficacy and safety of an evaluation strategy based on utilization of high sensitivity cardiac troponin T (hscTnT), followed by coronary computed tomography angiography (CCTA) in patients with low-intermediate risk chest pain consistent with a possible acute coronary syndrome compared to a standard of care (SOC) strategy.
• Unicentric, randomized, controlled, open label clinical trial that will compare a fast strategy (hscTnT followed by CCTA) with a SOC strategy (serial ECG and cardiac biomarkers followed by stress/rest imaging study).

Inclusion Criteria:

• Patients with chest pain consistent with possible acute coronary syndrome.
• Age > 18 years.
• Informed consent.

Exclusion Criteria:

• Previous history of coronary artery disease.
• Electrocardiogram diagnostic or suggestive of myocardial ischemia.
• Condition other than coronary artery disease as cause of an imbalance between myocardial oxygen supply and/or demand (eg. anemia, fever, arrhythmias).
• Chronic kidney disease (GFR <30 mL/min/1,73 m2).
• Iodine contrast allergy.
• Incapability to perform treadmill stress test.
• Barthel activity of daily living scale index < 100.