Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting

Impact of Perivascular Tissue on Endothelial Function and Vessel Structure in Vein Grafts Used for Coronary Artery Bypass Grafting: A Prospective, Randomized Controlled Trial.

The success of coronary artery bypass grafting is reliant on the quality of the grafts used. A new technique for harvesting veins used as grafts has been introduced. The study hypothesis is that veins harvested with this technique have an improved endothelial function.

Inclusion Criteria:

• Isolated elective, primary CABG requiring cardiopulmonary bypass
• Left ventricular ejection fraction >35%
• at least one saphenous vein graft required as part of revascularization strategy

Exclusion Criteria:

• Acute or chronic inflammatory diseases
• Malignancies
• Pregnancy
• Previous cardiac surgery
• Serum creatinine >120 μmol/L
• Coagulopathy
• Insulin dependent diabetes mellitus
• Smoking during last 6 months
• Leg not suitable for No-touch vein harvesting as judged by the operator.
• Need for nitrates on operation day
• not receiving statins