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| Name | Class |
|---|---|
| St. Olavs Hospital | OTHER |
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The success of coronary artery bypass grafting is reliant on the quality of the grafts used. A new technique for harvesting veins used as grafts has been introduced. The study hypothesis is that veins harvested with this technique have an improved endothelial function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| no-touch | Experimental | no-touch technique of harvesting the saphenous vein graft for coronary artery bypass grafting |
|
| conventional | Active Comparator | conventional technique of harvesting the saphenous vein graft for coronary artery bypass grafting |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no-touch | Procedure | The saphenous vein is exposed by a longitudinal incision, and all visible side branches ligated. The vein is then isolated together with a pedicle of surrounding tissue and manually distended and stored in a combination of blood and saline using a syringe, according to standard procedure at St. Olav's Hospital. |
| Measure | Description | Time Frame |
|---|---|---|
| Graft function | Graft function as evaluated by coronary angiography in the first 60 out of 100 patients | 6 months |
| Graft function | Graft function as evaluated by coronary angiography in all 100 patients | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Morphological appearance of vein graft | As measured by angiography follow-up in the first 60 out of 100 patients | 6 months |
| Morphological appearance of vein graft | As measured by angiography follow-up in all 100 patients |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dag Ole Nordhaug, md phd | Norwegian University of Science and Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute for Circulation and Imaging | Trondheim | Sør-Trøndelag | 7042 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27443441 | Result | Pettersen O, Wiseth R, Hegbom K, Nordhaug DO. Pedicled Vein Grafts in Coronary Surgery Exhibit Reduced Intimal Hyperplasia at 6 Months. J Am Coll Cardiol. 2016 Jul 26;68(4):427-9. doi: 10.1016/j.jacc.2016.04.058. No abstract available. | |
| 28648540 | Result | Pettersen O, Haram PM, Winnerkvist A, Karevold A, Wahba A, Stenvik M, Wiseth R, Hegbom K, Nordhaug DO. Pedicled Vein Grafts in Coronary Surgery: Perioperative Data From a Randomized Trial. Ann Thorac Surg. 2017 Oct;104(4):1313-1317. doi: 10.1016/j.athoracsur.2017.03.076. Epub 2017 Jun 23. |
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| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D003226 | Congresses as Topic |
| ID | Term |
|---|---|
| D009938 | Organizations |
| D004472 | Health Care Economics and Organizations |
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|
| conventional | Procedure | The saphenous vein is exposed by a longitudinal leg incision, skeletonized from surrounding tissue, and side branches ligated. The vein is removed from the leg immediately after dissection, manually distended and stored in a combination of blood and saline using a syringe, according to standard procedure at St. Olav's Hospital. |
|
| 5 years |
| Postoperative leg wound complications | The following measures will be assessed in the first 60 out of 100 patients:
| 6 weeks |
| Postoperative complications related to cardiac surgery | Major adverse cardiac and cerebral events in the first 60 out of 100 patients
| Discharge, 6 weeks, 6 months |
| Postoperative complications related to cardiac surgery | Major adverse cardiac and cerebral events in all 100 patients
| 5 years |
| 30444258 | Derived | Pettersen O, Pociask E, Malinowski KP, Slezak M, Hegbom K, Wiseth R, Nordhaug DO. Reproducibility of optical coherence tomography in vein grafts used for coronary revascularization. Cardiol J. 2020;27(5):518-523. doi: 10.5603/CJ.a2018.0139. Epub 2018 Nov 16. |