Autonomic Dysfunction in Resistant Hypertension

Circadian Autonomic Disturbances in Resistant Hypertension With and Without White-coat Phenomenon

The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.

All patients were submitted to office blood pressure measurement, Ambulatory blood pressure monitoring and 24-hour Holter monitoring.

Baseline blood samples for the measurement of glycemia (mg/dL), total cholesterol (mg/dL), LDL cholesterol (mg/dL), triglycerides (mg/dL), creatinine (mg/dL), serum uric acid, serum sodium, serum potassium, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were collected at 08:00 after overnight fasting.

Inclusion Criteria:

• resistant hypertensive patients

Exclusion Criteria:

• White-coat hypertension
• obstructive sleep apnea