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The beneficial effect of nocturnal sleep on memory consolidation is well-documented in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during nocturnal SWS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0,75 Hz stimulation | Experimental | slow transcranial oscillating stimulation (~0,75Hz) during periods of Slow Wave Sleep |
|
| SHAM stimulation | Experimental | SHAM stimulation during periods of Slow Wave Sleep |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| brain stimulation | Device | oscillating direct current brain stimulation |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS | Retention (difference values between performance at retrieval after sleep minus performance at learning before sleep) between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task. | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| 1. Amount of Slow wave Sleep | 1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS. | 4 weeks |
| 2. sleep spindels | 2. Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Agnes Flöel, Professor | Charite Universitätsmedizin Berlin - Neurologie | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charite CCM Neurologie Berlin | Berlin | State of Berlin | 10117 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17086200 | Background | Marshall L, Helgadottir H, Molle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. doi: 10.1038/nature05278. Epub 2006 Nov 5. | |
| 20046194 | Background | Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4. |
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| ID | Term |
|---|---|
| D046690 | Deep Brain Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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| SHAM |
| Device |
no stimulation |
|
| 4 weeks |
| 3. EEG-correlates | 3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task). | 4 weeks |
| 4. further memory systems | 4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS. | 4 weeks |