Adiponectin and Ethnic Differences in Insulin Resistance

Adiponectin as an Independent Determinant of Ethnic Differences in Insulin Resistance

The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.

Inclusion Criteria:

• 18-60 years of age
• BMI 20.0-34.9 m/kg2
• Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.

Exclusion Criteria:

• pregnancy
• breastfeeding
• diabetes mellitus
• blood pressure > 160/100 mmHg
• creatinine > 1.5 mg/dl or glomerular filtration rate (GFR) < 60
• liver function tests > 3x upper limit of normal (ULN)
• h/o heart failure
• h/o eating disorder