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This was a Non-interventional Prospective Study. Centres enrolled adult patients with partial-onset seizures with or without secondary generalisation for whom the clinician had decided to initiate Eslicarbazepine Acetate (ESL) as an adjunctive therapy prior to the decision to take part in this study. Patients enrolled into the study were not sufficiently controlled with one drug licensed for the use as monotherapy in partial-onset seizures. Patients were seen at baseline and then during normal clinical visits at intervals. Patients in this study were assessed for efficacy and tolerability at baseline and then at least 3 and 6 months after the baseline.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Eslicarbazepine Acetate tablets |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Eslicarbazepine Acetate tablets | Drug | The Eslicarbazepine Acetate (ESL) Summary of Product Characteristics (SPC) recommended a starting dose of 400 mg once-daily (QD) which was increased to 800 mg QD after one or two weeks. Based on individual response, the dose was increased to 1200 mg QD. Treatment decisions were made by clinicians in agreement with the participant, and were independent of participation in the study. |
| Measure | Description | Time Frame |
|---|---|---|
| Retention Rate of Eslicarbazepine Acetate (ESL) After 6 months from Baseline | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Overall Seizure Frequency after 3 and 6 months from Baseline | Change in overall seizure frequency calculated as absolute and percent changes after 3 and 6 months from baseline compared to the seizure frequency 3 months before introduction of ESL. | Baseline, 3 months and 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Normal clinical practice setting/ centre.
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| Name | Affiliation | Role |
|---|---|---|
| Martin Holtkamp, Dr. | Klinische und Experimentelle Epileptologie | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hradec Králové | Czechia | |||||
| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 24, 2016 | |
| Unrelease | Yes | |
| Release | Jun 23, 2016 |
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|
|
| Kroměříž |
| Czechia |
| Prague | Czechia |
| Aalborg | Denmark |
| Arhus C | Denmark |
| Copenhagen | Denmark |
| Dianalund | Denmark |
| Esbjerg | Denmark |
| Glostrup Municipality | Denmark |
| Holstebro | Denmark |
| Roskilde | Denmark |
| Sønderborg | Denmark |
| Vejle | Denmark |
| Altkirch | France |
| Armentières | France |
| Bergerac | France |
| Biarritz | France |
| Chaumont | France |
| Cholet | France |
| Gap | France |
| Nice | France |
| Nîmes | France |
| Paris | France |
| Perpignan | France |
| Rueil-Malmaison | France |
| Sarreguemines | France |
| Toulon | France |
| Altenholz | Germany |
| Asperg | Germany |
| Augsburg | Germany |
| Bad Berka | Germany |
| Bad Langensalza | Germany |
| Berlin | Germany |
| Beuel | Germany |
| Bielefeld | Germany |
| Bochum | Germany |
| Bockhorn | Germany |
| Buxtehude | Germany |
| Cologne | Germany |
| Dortmund | Germany |
| Erbach im Odenwald | Germany |
| Erlangen | Germany |
| Etville | Germany |
| Gelsenkirchen | Germany |
| Gera | Germany |
| Greiz | Germany |
| Grevenbroich | Germany |
| Guelders | Germany |
| Hamburg | Germany |
| Hamm | Germany |
| Heilbad Heiligenstadt | Germany |
| Herdecke | Germany |
| Hildesheim | Germany |
| Hof | Germany |
| Ilmenau | Germany |
| Itzehoe | Germany |
| Kamp-Lintfort | Germany |
| Kirchen (Sieg) | Germany |
| Königsbrück | Germany |
| Leipzig | Germany |
| Leverkusen | Germany |
| Lohr a. Main | Germany |
| Ludwigsburg | Germany |
| Mannheim | Germany |
| Mittweida | Germany |
| München | Germany |
| Oranienburg | Germany |
| Osnabrück | Germany |
| Quakenbrück | Germany |
| Rathenow | Germany |
| Salzgitter | Germany |
| Schirgiswalde-Kirschau | Germany |
| Schorndorf | Germany |
| Schwäbisch Gmünd | Germany |
| Senftenberg | Germany |
| Solingen | Germany |
| Stuttgart | Germany |
| Troisdorf (Sieglar) | Germany |
| Waiblingen | Germany |
| Wesel | Germany |
| Westerstede | Germany |
| Wilhelmshaven | Germany |
| Wolfsburg | Germany |
| Würzburg | Germany |
| Dooradoyle/ Co. Limerick | Ireland |
| Dublin | Ireland |
| Bergen | Norway |
| Molde | Norway |
| Oslo | Norway |
| Skien | Norway |
| Angered | Sweden |
| Helsingborg | Sweden |
| Kungsbacka | Sweden |
| Linköping | Sweden |
| Stockholm / Saint Goran | Sweden |
| Birmingham | United Kingdom |
| Dundee | United Kingdom |
| London | United Kingdom |
| Middlesbrough | United Kingdom |
| Newport | United Kingdom |
| Romford | United Kingdom |
| Salford | United Kingdom |
| Stoke-on-Trent | United Kingdom |
| Telford | United Kingdom |
| Torquay, Devon | United Kingdom |
| Truro | United Kingdom |
| Reset | Aug 3, 2016 |
| Release | Nov 17, 2016 |
| Reset | Jan 13, 2017 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 24, 2016 | Yes | |||
| Jun 23, 2016 | Aug 3, 2016 | |||
| Nov 17, 2016 | Jan 13, 2017 |
| ID | Term |
|---|---|
| C416835 | eslicarbazepine acetate |
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