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Irritable bowel syndrome (IBS) is a chronic gastrointestinal illness of unknown cause whose symptoms include abdominal pain, bloating and altered bowel pattern. Diet has been shown to influence the bacteria gut interaction. Our aim is to determine if components of the diet affect IBS symptoms by changing the bacteria gut interaction. In particular, we will measure whether after being on a diet high or low on certain factors there is a change in the timing and amount of hydrogen and methane produced by bacteria digesting lactulose and on IBS symptom severity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Factor Diet | Active Comparator | Patients will be on a factor altered diet to see effects on their lactulose breath test and symptoms. |
|
| Low Factor Diet | Active Comparator | Patients will be on a factor altered diet to assess its effects on symptoms and lactulose breath test. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Factor Altered Diet | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under the Curve of Hydrogen Gas on Lactulose Breath Test | 5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Area Under the Curve on Lactulose Breath Test from Baseline | 5 hours | |
| Change in IBS Symptom Severity Score from Baseline | 3 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephen Vanner, MD, FRCPC | Queen's University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hotel Dieu Hospital | Kingston | Ontario | K7L 5G2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26976734 | Derived | McIntosh K, Reed DE, Schneider T, Dang F, Keshteli AH, De Palma G, Madsen K, Bercik P, Vanner S. FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial. Gut. 2017 Jul;66(7):1241-1251. doi: 10.1136/gutjnl-2015-311339. Epub 2016 Mar 14. |
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| ID | Term |
|---|---|
| D043183 | Irritable Bowel Syndrome |
| ID | Term |
|---|---|
| D003109 | Colonic Diseases, Functional |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| D004066 | Digestive System Diseases |