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In patients with gallbladder in situ after complete removal of common bile duct (CBD) stones, there is no definite guideline for the management of remnant acalculous gallbladder. This study was planned to evaluate the efficacy of choleretic agents in those patients comparing with non-treatment group during short (2 years) and long-term (5 to 10 years) period. So that, the investigators want to establish the treatment guideline in gallbladder in situ without definite stones following complete removal of CBD stones. Second, the protective or preventive effect of choleretics may be defined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Wait-and-see group | After endoscopic clearance of their bile duct stones, this group of patients will be follow up without additional managements | ||
| Choleretics group | After endoscopic clearance of their bile duct stones, this group of patients receives choleretic agents during 3 months |
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| Measure | Description | Time Frame |
|---|---|---|
| Complications | The primary outcome is biliary complications between two groups during follow-up. | two year |
| Measure | Description | Time Frame |
|---|---|---|
| Natural outcomes | Other outcome measures included adverse events after choleretics and natural clinical courses of gallbladder in situ. | two year |
| Other adverse events | Other outcome measures included adverse events after choleretics and natural outcomes of gallbladder in situ. |
| Measure | Description | Time Frame |
|---|---|---|
| Drug-related adverse event | Other outcome measure includes adverse events after choleretics. | three months |
Inclusion Criteria:
Exclusion Criteria:
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We randomized patients (>18 years of age) who underwent therapeutic endoscopic biliary sphincterotomy and/or balloon dilation for the complete clearance of their bile duct stones.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tae Hoon Lee, MD, PhD | Contact | +82-41-570-3662 | thlee9@schmc.ac.kr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Soon Chun Hyang University Cheonan Hospital | Recruiting | Cheonan | Chungcheongnam-do | 330-721 | South Korea |
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| ID | Term |
|---|---|
| D042882 | Gallstones |
| ID | Term |
|---|---|
| D002769 | Cholelithiasis |
| D001660 | Biliary Tract Diseases |
| D004066 | Digestive System Diseases |
| D041761 | Cholecystolithiasis |
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| two year |
| D005705 |
| Gallbladder Diseases |
| D002137 | Calculi |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |