Prevalence of Non Celiac Gluten Sensitivity Among Patients Spontaneously Adherent to Gluten Free Diet

Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial With a Cross-over Design to Assess the Prevalence of Non Celiac Gluten Sensitivity Among Patients Spontaneously Adherent to Gluten Free Diet

The purpose of this study is to assess the prevalence of Gluten Sensitivity, by a double-blind placebo-controlled challenge with gluten, followed by two months period of Low-FODMAPs (Fermentable Oligosaccharides Disaccharides Monosaccharides And Polyols) diet, in patients spontaneously adherent to gluten free diet because of symptoms upon gluten exposure and in whom diagnosis of Celiac Disease and Wheat Allergy has been ruled out.

Inclusion Criteria:

• Adherence to gluten free diet without medical need
• Negative Celiac Disease related serology (while on gluten containing diet)
• Normal villous structure at duodenal biopsy (while on gluten containing diet)

Exclusion Criteria:

• Diagnosis of Celiac Disease
• Diagnosis of Wheat Allergy
• Diagnosis of organic gastrointestinal disease
• Severe concomitant disease