Promethazine vs. Lorazepam for Treatment of Vertigo

Promethazine vs. Lorazepam for Treatment of Vertigo in the Emergency Department: A Randomized Clinical Trial

This study was a prospective, randomized, double-blind, parallel group clinical trial designed to compare the efficacy of intravenous (IV) promethazine and lorazepam for the treatment of peripheral vertigo in Emergency Department setting.

Inclusion Criteria:

• Aged 18 years or older
• Background history of positional vertigo

Exclusion Criteria:

• Unable to provide informed consent
• Pregnant or possibly pregnant
• Known allergy to study medications
• Use of antiemetic agents in the previous 24 hours
• Evidence of drug-induced vertigo or orthostatic hypotension
• Central pathologies/central origin for vertigo