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| ID | Type | Description | Link |
|---|---|---|---|
| Saving Brains #0058 | Other Grant/Funding Number | Grand Challenges Canada | |
| ISRCTN65316374 | Registry Identifier | International Standard Randomised Controlled Trial Number |
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| Name | Class |
|---|---|
| Human Development Research Foundation, Pakistan | OTHER |
| Grand Challenges Canada | OTHER |
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The purpose of this study is to examine whether the successful perinatal depression intervention among mothers (Thinking Healthy Programme, THP) has led to improved developmental outcomes in the children 6 years later. Economic and human resources aspects of the intervention will also be evaluated to determine overall societal benefits from investment in such a program, feasibility of scaling up the intervention and its sustainability in the long-term. The primary hypothesis is that children of mothers who participated in the THP will have better cognitive outcomes and socio-emotional functioning when compared to children of mothers randomized to the control group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| depressed mother/child dyad - intervention | |||
| depressed mother/child dyad - no intervention | |||
| non-depressed mother/child dyad |
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| Measure | Description | Time Frame |
|---|---|---|
| Estimate of general intelligence | Re-enrollment visit, approximately 7 years post-intervention | |
| Measures of executive functions | Working memory, cognitive flexibility, inhibitory control, and sustained attention will be measured by standard tests of cognitive functioning. | Re-enrollment visit, approximately 7 years post-intervention |
| Level of literacy and numeracy | Re-enrollment visit, approximately 7 years post-intervention | |
| Presence of behavioral and emotional problems (socio-emotional development) | Re-enrollment visit, approximately 7 years post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Height-for-age | Re-enrollment visit, approximately 7 years post-intervention | |
| Weight-for-age | Re-enrollment visit, approximately 7 years post-intervention |
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Inclusion Criteria:
Exclusion Criteria:
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The study population includes children of women who participated in the Thinking Healthy Programme and children of women who were eligible for participation in the Thinking Healthy Programme but who screened negative for depression at the time.
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| Name | Affiliation | Role |
|---|---|---|
| Joanna Maselko, ScD | Duke University | Principal Investigator |
| Siham Sikander, PhD | Human Development Research Foundation, Pakistan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Human Development Research Foundation | Islamabad | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18790313 | Background | Rahman A, Malik A, Sikander S, Roberts C, Creed F. Cognitive behaviour therapy-based intervention by community health workers for mothers with depression and their infants in rural Pakistan: a cluster-randomised controlled trial. Lancet. 2008 Sep 13;372(9642):902-9. doi: 10.1016/S0140-6736(08)61400-2. |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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