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The purpose of this study is primarily to determine the effects of propofol at different concentration on the mitral valve annulus by using Tissue Doppler Imaging
The purpose of this study is to evaluate the effects of different concentration of propofol on patients who are undergoing cardiac surgery. The patients will receive infusion remifentanil 0.5mcg/kg/min with different target-site propofol concentration namely 1.0ng/ml, 2.0ng/ml and 3.0ng/ml. Tissue Doppler Imaging by transesophageal echocardiography will be done to assess the changes in cardiac function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol 1.0mcg | Experimental | Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 1.0mcg/ml using target controlled infusion. |
|
| Propofol 2.0mcg | Experimental | Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 2.0mcg/ml using target controlled infusion. |
|
| Propofol 3.0mcg | Experimental | Propofol dosage titration, comparison of the effect of different concentration of propofol to the myocardial performances, namely at 3.0mcg/ml using target controlled infusion. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol 1.0mcg | Drug | Propofol dosage titration to achieve effect site concnetration at 1.0 mcg/ml using target controlled infusion. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of systolic mitral valve annular velocity (S') | To examine the effect of Propofol at different effect-site concentration ( 1.0 ng/ml, 2.0 ng/ml and 3.0 ng/ml) on S' (systolic mitral valve annular velocity) during remifentanil-based anesthesia. | 10 min after achieving 3 different propofol concentrations |
| Measure | Description | Time Frame |
|---|---|---|
| Early diastolic mitral valve annular velocity (e') | 10 min after achieving 3 different propofol concentrations | |
| late diastolic (atrial contractile) mitral valve annular velocity (a') | 10 min after achieving 3 different propofol concentrations |
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Inclusion Criteria:
patients undergoing cardiac surgery
Exclusion Criteria:
low ejection fraction < 50% on transthoracic echocardiography atrial fibrillation pacemaker pericardial and infiltrative myocardial disease mitral annular calcification, surgical rings, prosthetic mitral valve lateral left ventricular wall motion abnormality oesophageal abnormality history of extensive radiation to the mediastinum upper gastrointestinal bleeding
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| Name | Affiliation | Role |
|---|---|---|
| Tae-yop Kim, MD, PhD | Konkuk University Medical Center, Seoul, Korea, Republic of | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Konkuk University Medical Center | Seoul | Seoul | 143-729 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31020819 | Derived | Bang JY, Kim S, Choi BM, Kim TY. Pharmacodynamic Analysis of the Influence of Propofol on Left Ventricular Long-Axis Systolic Performance in Cardiac Surgical Patients. J Korean Med Sci. 2019 Apr 29;34(16):e132. doi: 10.3346/jkms.2019.34.e132. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 15, 2016 | |
| Reset | Jan 11, 2017 | |
| Release | Jan 13, 2017 | |
| Reset | Mar 3, 2017 | |
| Release | Mar 19, 2018 | |
| Reset | Nov 2, 2018 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 15, 2016 | Jan 11, 2017 | |||
| Jan 13, 2017 |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Propofol 2.0mcg | Drug | Propofol dosage titration to achieve effect site concnetration at 2.0 mcg/ml using target controlled infusion. |
|
|
| Propofol 3.0mcg | Drug | Propofol dosage titration to achieve effect site concnetration at 3.0 mcg/ml using target controlled infusion |
|
|
| ejection fraction | 10 min after achieving 3 different propofol concentrations |
| phenylephrine infusion rate | 10 min after achieving 3 different propofol concentrations |
| Mar 3, 2017 |
| Mar 19, 2018 | Nov 2, 2018 |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |