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| ID | Type | Description | Link |
|---|---|---|---|
| 2012-000619-10 | EudraCT Number |
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The purpose of the study is to determine whether there are differences in pancreatic uptake of the radiotracer between healthy individuals and patients with type 1 diabetes. If T1D patients have a markedly reduced uptake, the compound may be suitable for estimation of pancreatic beta cell mass, i.e. the cells in the pancreas that produce insulin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 1 Diabetes | patients with long standing T1D |
| |
| Healthy volunteer | healthy volunteers with normal glucose tolerance |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| radiolabeled Exendin | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| pancreatic uptake of radiolabeled Exendin | uptake will be given as counts per MBq injected activity as determined by calibrated SPECT/CT scanner with attenuation correction. | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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Type 1 Diabetes patients and healthy volunteers responding to advertisment
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Radboud University Nijmegen Medical Center | Nijmegen | Gelderland | 6500 HB | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24488022 | Derived | Brom M, Woliner-van der Weg W, Joosten L, Frielink C, Bouckenooghe T, Rijken P, Andralojc K, Goke BJ, de Jong M, Eizirik DL, Behe M, Lahoutte T, Oyen WJ, Tack CJ, Janssen M, Boerman OC, Gotthardt M. Non-invasive quantification of the beta cell mass by SPECT with (1)(1)(1)In-labelled exendin. Diabetologia. 2014 May;57(5):950-9. doi: 10.1007/s00125-014-3166-3. Epub 2014 Feb 1. |
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| ID | Term |
|---|---|
| D003922 | Diabetes Mellitus, Type 1 |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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blood samples
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |