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| Name | Class |
|---|---|
| University Hospital Goettingen | OTHER |
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It is the aim of the present study to assess the prevalence of ASS-Nonresponse following cardiac surgery using the Multiple Electrode Aggregometry (MEA).
Up to now there are no data concerning the prevalence of ASS-Nonresponse following surgical coronary revascularization procedures as assessed with the Multiple Electrode Aggregometry. Results of the present observational study are needed to assess the prevalence of ASS-Nonresponse in order to perform a sample size analysis for a prospective interventional study in a second step.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CABG Patients | Patients undergoing surgery for coronary revascularization. |
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| Measure | Description | Time Frame |
|---|---|---|
| ASPItest | Area under the aggregation curve following stimulation with arachidonic acid in the Multiple Electrode Aggregometry (MEA) | at day 3 and 5 after the first dose of aspirin following surgery |
| Measure | Description | Time Frame |
|---|---|---|
| TRAPtest | Area under the aggregation curve in the Multiple Electrode Aggregometry following stimulation with thrombin receptor activating peptide 6 | at day 3 and 5 after the first dose of aspirin following surgery |
| Platelet Count |
| Measure | Description | Time Frame |
|---|---|---|
| Age | Age of the patient in years at the time of enrollment | at the day of enrollment |
| Height | Height of the patient in centimeters at the time of enrollment |
Inclusion Criteria:
Exclusion Criteria:
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Patients following cardiac surgery and a antiaggregatory therapy with aspirin
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| Name | Affiliation | Role |
|---|---|---|
| Christian F Weber, MD | Goethe University Frankfurt | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Goethe - University | Frankfurt am Main | Hesse | 60590 | Germany | ||
| University Hospital Goettingen |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23121439 | Background | Collet JP, Cuisset T, Range G, Cayla G, Elhadad S, Pouillot C, Henry P, Motreff P, Carrie D, Boueri Z, Belle L, Van Belle E, Rousseau H, Aubry P, Monsegu J, Sabouret P, O'Connor SA, Abtan J, Kerneis M, Saint-Etienne C, Barthelemy O, Beygui F, Silvain J, Vicaut E, Montalescot G; ARCTIC Investigators. Bedside monitoring to adjust antiplatelet therapy for coronary stenting. N Engl J Med. 2012 Nov 29;367(22):2100-9. doi: 10.1056/NEJMoa1209979. Epub 2012 Nov 4. |
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Platelet count taken from the daily standard laboratory results.
| at day 3 and 5 after the first dose of aspirin following surgery |
| Mortality | Mortality will be assessed by a telephonic follow up interview 12 month after enrollment into the study | 12 month |
| Myocardial infarction | Occurrence of a myocardial infarction during the 12 month following surgery assessed in a telephonic follow up interview. | 12 month |
| Readmission to hospital | Did a readmission to hospital due to cardiac or pulmonary reasons take place in the 12 month following enrollment into the study? Assessed by a telephonic follow up interview. | 12 month |
| at the day of enrollment |
| Weight | Weight of the patient in kilograms at enrollment | at the day of enrollment |
| Gender | Gender of the patient | at the day of enrollment |
| LDL cholesterol | LDL cholesterol of the patient in mg/dl at enrollment | at the day of enrollment |
| nicotine | Smoking habits of the patient will be documented at enrollment in the categories:
| at the day of enrollment |
| European system for cardiac operative risk evaluation (EuroSCORE) | EuroSCORE as assessed on admission will be documented. | at the day of enrollment |
| Diabetes | Risk factor diabetes will be documented in the following categories at enrollment:
| at the day of enrollment |
| Surgical procedure | The surgical procedure performed will be documented. | at the day of enrollment |
| phone number | The phone will be documented for the 12 month follow up interview. | at the day of enrollment |
| Göttingen |
| Lower Saxony |
| 37073 |
| Germany |