Efficacy of G-CSF in the Management of Steroid Non-responsive Severe Alcoholic Hepatitis

Efficacy of G-CSF in the Management of Steroid Non-responsive Severe Alcoholic Hepatitis. - A Double Blind Randomized Control Trial.

After successful screening, first the investigators first treat patients of severe alcoholic hepatitis with steroids for 7 days. Patients who are found to be unresponsive as per Lille's score [>0.45] would be randomized into either placebo group or G-CSF group. Responders to steroids will continue on steroids for 28 days followed by 2 weeks of tapering. Non responders will be randomized to receive G-CSF for 28days.

Inclusion Criteria:

- Severe alcoholic hepatitis patients [Maddrey's score > 32] aged between 18 to 65 years.

Exclusion Criteria:

• Presence of active infections
• Acute GI bleed
• Hepatorenal syndrome
• Patient unwilling
• DF>120
• Autoimmune hepatitis
• Hepatitis B, Hepatitis C, HIV cases
• Pregnancy