Pulse Pressure Variation for Prediction of Fluid Responsiveness in Coronary Artery Disease Patients With Diastolic Dysfunction

The investigators hypothesized that predictability of pulse pressure variation (PPV) on fluid responsiveness would be reduced in patients with coronary disease who have diastolic dysfunction.

Inclusion Criteria:

• Patients older than 20 years
• scheduled for elective coronary artery bypass grafting
• normal diastolic function (E/E' < 8) or diastolic dysfunction (E/E' >15) according to preoperative Echocardiographic evaluation

Exclusion Criteria:

• arrythmia,
• reduced left ventricular function (ejection fraction < 40%)
• valvular heart disease requiring concomitant surgical correction
• pulmonary hypertension (mean pulmonary arterial pressure ≥30 mm Hg)
• peripheral arterial occlusive disease, pulmonary disease (asthma, chronic obstructive pulmonary disease, and lung resection)
• end-stage renal disease