The purpose of this trial is to evaluate the effect of a single PPC-5650 dose in a human pain model including multimodal (mechanical, thermal, electrical, chemical) stimulations of the esophagus.

Inclusion Criteria:

• Signed informed consent before any study specific procedures
• Able to read and understand Danish.
• Healthy i.e. no history of chronic or recurrent pain rewarding diseases
• Able to co-operate and tolerate the experimental procedures (as assessed in the training visit)
• No over the counter medication 24h before the three visits
• No medications in the study period
• BMI 18.5-35.0
• Caucasian
• No symptoms of Gastroesophageal reflux disease
• All men must use a safe method of contraception during the study period

Exclusion Criteria:

• Any clinically relevant abnormal values from the laboratory tests on hematology, clinical chemistry, and/or urine analyses, as judged by the investigator.
• Participation in any other clinical trial within three months prior to the training day.
• Alcohol or drug abuse.
• Mental illnesses
• Allergic to the active ingredient in the investigational medicinal product